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Bioinspired AdhesivenAntibacterial Hydrogel with Self-Healingnand On-Demand Removability for Enhanced Full-Thickness Skin WoundnRepair 生物灵感粘合剂抗菌水凝胶，具有自愈和按需去除性，增强全层皮肤伤口修复

Figshare Pub Date : 2023-10-06 DOI: 10.1021/acs.biomac.3c00576.s001

Minwei Yang (9938977), Jing Tian (335437), Kaiwen Zhang (9282671), Xu Fei (5039870), Fawen Yin (5977838), Longquan Xu (3195795), Yi Wang (32470), Yao Li (154923)

{"title":"Bioinspired AdhesivenAntibacterial Hydrogel with Self-Healingnand On-Demand Removability for Enhanced Full-Thickness Skin WoundnRepair","authors":"Minwei Yang (9938977), Jing Tian (335437), Kaiwen Zhang (9282671), Xu Fei (5039870), Fawen Yin (5977838), Longquan Xu (3195795), Yi Wang (32470), Yao Li (154923)","doi":"10.1021/acs.biomac.3c00576.s001","DOIUrl":"https://doi.org/10.1021/acs.biomac.3c00576.s001","url":null,"abstract":"Adhesive-causedninjury is a great threat for extensive full-thicknessnskin trauma because extra-strong adhesion can incur unbearable painnand exacerbate trauma upon removal. Herein, inspired by the mussel,nwe designed and fabricated an adhesive antibacterial hydrogel dressingnbased on dynamic host–guest interaction that enabled on-demandnstimuli-triggered removal to effectively care for wounds. In contrastnwith most hard-to-removable dressing, this adhesive antibacterialnhydrogel exhibited strong adhesion property (85 kPa), which couldnachieve painless and noninvasive on-demand separation within 2 s throughna host–guest competition mechanism (amantadine). At the samentime, the hydrogel exhibited rapid self-healing properties, and thenbroken hydrogel could be completely repaired within 5 min. The hydrogelnalso had excellent protein adsorption properties, mechanical properties,nantibacterial properties, and biocompatibility. This on-demand removalnwas facilitated by the introduction of amantadine as a competitivenguest, without any significant adverse effects on cell activity (>90%)nor wound healing (98.5%) <i>in vitro</i>. The full-thicknessnrat-skin defect model and histomorphological evaluation showed thatnthe hydrogel could significantly promote wound healing and reducenscar formation by regulating inflammation, accelerating skin re-epithelialization,nand promoting granulation tissue formation. These results indicatenthat the developed adhesive antibacterial hydrogel offers a promisingntherapeutic strategy for the healing of extensive full-layer skinninjuries.","PeriodicalId":523609,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147918960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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