Figshare最新文献

筛选

英文中文

Hybrid AmyloidnQuantum Dot Nano-Bio Assemblies tonProbe Neuroinflammatory Damage 混合淀粉样蛋白/量子点纳米生物组件探测神经炎症损伤

Figshare Pub Date : 2024-08-15 DOI: 10.1021/acschemneuro.4c00183.s004

Wesley Chiang (10271219), Jennifer M. Urban (6685349), Francine Yanchik-Slade (16793336), Angela Stout (16793333), Jennetta M. Hammond (19429399), Bradley L. Nilsson (1421248), Harris A. Gelbard (206998), Todd D. Krauss (1299201)

{"title":"Hybrid AmyloidnQuantum Dot Nano-Bio Assemblies tonProbe Neuroinflammatory Damage","authors":"Wesley Chiang (10271219), Jennifer M. Urban (6685349), Francine Yanchik-Slade (16793336), Angela Stout (16793333), Jennetta M. Hammond (19429399), Bradley L. Nilsson (1421248), Harris A. Gelbard (206998), Todd D. Krauss (1299201)","doi":"10.1021/acschemneuro.4c00183.s004","DOIUrl":"https://doi.org/10.1021/acschemneuro.4c00183.s004","url":null,"abstract":"Various oligomeric species of amyloid-beta have beennproposed tonplay different immunogenic roles in the cellular pathology of Alzheimer’snDisease. The dynamic interconversion between various amyloid oligomersnand fibrillar assemblies makes it difficult to elucidate the roleneach potential aggregation state may play in driving neuroinflammatorynand neurodegenerative pathology. The ability to identify the amyloidnspecies that are key and essential drivers of these pathological hallmarksnof Alzheimer’s Disease is of fundamental importance for alsonunderstanding downstream events including tauopathies that mediatenneuroinflammation with neurologic deficits. Here, we report the designnand construction of a quantum dot mimetic for larger spherical oligomericnamyloid species as an “endogenously” fluorescent proxynfor this cytotoxic assembly of amyloid to investigate its role inninducing inflammatory and stress response states in neuronal and glialncell types. The design parameters and construction protocol developednhere may be adapted for developing quantum dot nano-bio assembliesnfor other biological systems of interest, particularly neurodegenerativendiseases involving other protein aggregates.","PeriodicalId":523554,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147918100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0