FigsharePub Date : 2021-08-30DOI: 10.1021/acs.jafc.1c04032.s001
Shanshan Hu (161684), Shi Li (169084), Yan Liu (25061), Kang Sun (630771), Liyong Luo (8905400), Liang Zeng (791005)
{"title":"Aged Ripe Pu-erh Tea Reduced Oxidative Stress-MediatednInflammation in Dextran Sulfate Sodium-Induced Colitis Mice by RegulatingnIntestinal Microbes","authors":"Shanshan Hu (161684), Shi Li (169084), Yan Liu (25061), Kang Sun (630771), Liyong Luo (8905400), Liang Zeng (791005)","doi":"10.1021/acs.jafc.1c04032.s001","DOIUrl":"https://doi.org/10.1021/acs.jafc.1c04032.s001","url":null,"abstract":"Ripened pu-erh tea has the biologicalnactivity of antioxidationnand anti-inflammation, which inhibits the related parameters of colitis.nHowever, the role of storage-induced changes in bioactive ingredientsnof ripened pu-erh tea in colitis remains unclear. In this study, 3.5%ndextran sulfate sodium-induced colitis mice were treated with 10 mg/kgnbw/day extracts, aged 14 years (P2006) and unaged (P2020) ripenednpu-erh tea, respectively, for 1 week. We found that ripened pu-erhntea, especially P2006, inhibited the intestinal oxidative stress-mediatedninflammation pathway (TLR4/MyD88/ROS/p38MAPK/NF-κB p65), upregulatednthe expression of intestinal tight junction proteins (Mucin-2, ZO-1,noccludin), promoted M2 polarization of macrophages, and in turn, improvednthe intestinal immune barrier, which stemmed from the reshaping ofnintestinal microbiota (e.g., increased <i>Lachnospiraceae_NK4A136_group</i> and <i>Akkermansia</i> levels). Our results speculatenthat drinking aged ripe pu-erh tea (10 mg/kg bw/day in mice, a humannequivalent dose of 7 g/60 kg bw/day) has a practical effect on alleviatingnand preventing the development of intestinal inflammation.","PeriodicalId":523420,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://figshare.com/articles/journal_contribution/Aged_Ripe_Pu-erh_Tea_Reduced_Oxidative_Stress-Mediated_Inflammation_in_Dextran_Sulfate_Sodium-Induced_Colitis_Mice_by_Regulating_Intestinal_Microbes/16543301","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147915652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}