Figshare最新文献

筛选
英文 中文
Expression andnSubcellular Localization of Lanthipeptidesnin Human Cells Lanthipeptides nn在人细胞中的表达及亚细胞定位
Figshare Pub Date : 2024-06-26 DOI: 10.1021/acssynbio.4c00178.s001
Sara M. Eslami (18889074), Chandrashekhar Padhi (18347453), Imran R. Rahman (14685930), Wilfred A. van der Donk (7471073)
{"title":"Expression andnSubcellular Localization of Lanthipeptidesnin Human Cells","authors":"Sara M. Eslami (18889074), Chandrashekhar Padhi (18347453), Imran R. Rahman (14685930), Wilfred A. van der Donk (7471073)","doi":"10.1021/acssynbio.4c00178.s001","DOIUrl":"https://doi.org/10.1021/acssynbio.4c00178.s001","url":null,"abstract":"Cyclic peptides,nsuch as most ribosomally synthesized and post-translationallynmodified peptides (RiPPs), represent a burgeoning area of interestnin therapeutic and biotechnological research because of their conformationalnconstraints and reduced susceptibility to proteolytic degradationncompared to their linear counterparts. Herein, an expression systemnis reported that enables the production of structurally diverse lanthipeptidesnand derivatives in mammalian cells. Successful targeting of lanthipeptidesnto the nucleus, the endoplasmic reticulum, and the plasma membranenis demonstrated. In vivo expression and targeting of such peptidesnin mammalian cells may allow for screening of lanthipeptide-basedncyclic peptide inhibitors of native, organelle-specific protein–proteinninteractions in mammalian systems.","PeriodicalId":523403,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147915327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书