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Inhalable siRNA Nanoparticlesnfor Enhanced Tumor-TargetingnTreatment of KRAS-Mutant Non-Small-Cell Lung Cancer 可吸入siRNA纳米颗粒增强肿瘤靶向治疗KRAS&lt；/i&gt；-突变非小细胞肺癌

Figshare Pub Date : 2023-06-24 DOI: 10.1021/acsami.3c05007.s001

Guolin Zhao (3322245), William Ho (2139412), Jinxian Chu (16440513), Xiaojian Xiong (16440516), Bin Hu (122268), Kofi Oti Boakye-Yiadom (16440519), Xiaoyang Xu (1865383), Xue-Qing Zhang (1273854)

{"title":"Inhalable siRNA Nanoparticlesnfor Enhanced Tumor-TargetingnTreatment of KRAS-Mutant Non-Small-Cell Lung Cancer","authors":"Guolin Zhao (3322245), William Ho (2139412), Jinxian Chu (16440513), Xiaojian Xiong (16440516), Bin Hu (122268), Kofi Oti Boakye-Yiadom (16440519), Xiaoyang Xu (1865383), Xue-Qing Zhang (1273854)","doi":"10.1021/acsami.3c05007.s001","DOIUrl":"https://doi.org/10.1021/acsami.3c05007.s001","url":null,"abstract":"Kirsten rat sarcoma (KRAS) isnthe most commonly mutated oncogene in lung cancers. Gene therapy isnemerging as a promising cancer treatment modality; however, the systemicnadministration of gene therapy has been limited by inefficient deliverynto the lungs and systemic toxicity. Herein, we report a noninvasivenaerosol inhalation nanoparticle (NP) system, termed “siKRAS@GCLPP NPs,” to treat KRAS-mutantnnon-small-cell lung cancer (NSCLC). The self-assembled siKRAS@GCLPP NPs are capable of maintaining structural integrity duringnnebulization, with preferential distribution within the tumor-bearingnlung. Inhalable siKRAS@GCLPP NPs show not only significantntumor-targeting capability but also enhanced antitumor activity innan orthotopic mouse model of human KRAS-mutant NSCLC.nThe nebulized delivery of siKRAS@GCLPP NPs demonstratesnpotent knockdown of mutated KRAS in tumor-bearingnlungs without causing any observable adverse effects, exhibiting anbetter biosafety profile than the systemic delivery approach. Thenresults present a promising inhaled gene therapy approach for thentreatment of KRAS-mutant NSCLC and other respiratoryndiseases.","PeriodicalId":523371,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147914756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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