FigsharePub Date : 2018-02-08DOI: 10.1021/acsanm.7b00255.s001
Chunyu Yang (269294), Chongshen Guo (1966351), Wei Guo (86150), Xiaole Zhao (2603575), Shaoqin Liu (1694335), Xiaojun Han (1653919)
{"title":"Multifunctional Bismuth Nanoparticles as TheranosticnAgent for PA/CT Imaging and NIR Laser-Driven Photothermal Therapy","authors":"Chunyu Yang (269294), Chongshen Guo (1966351), Wei Guo (86150), Xiaole Zhao (2603575), Shaoqin Liu (1694335), Xiaojun Han (1653919)","doi":"10.1021/acsanm.7b00255.s001","DOIUrl":"https://doi.org/10.1021/acsanm.7b00255.s001","url":null,"abstract":"“One-for-all”nmultifunctional theranostic agentsnare highly demanded in biomedical fields. However, their design andnfabrication still face enormous challenges. Herein, we strategicallyndesign and fabricate 1,2-dilauroyl-<i>sn</i>-glycero-3-phosphocholine-modifiedn(DLPC-modified) bismuth nanoparticles (denoted as Bi@DLPC NPs) withndesirable size of 47 ± 3 nm as a theranostic agent for photoacousticn(PA) and X-ray computed tomography (CT) imaging guided photothermalntherapy (PTT) in response to near-infrared (NIR) laser irradiation.nBi@DLPC NPs possess the excellent photothermal conversion efficiencynof 35% and PA/CT imaging properties, which are attributed to the strongnNIR absorption and high atomic number (83) of bismuth element. Moreover,nit is demonstrated that Bi@DLPC NPs are effectively accumulated innthe tumor region because of the enhanced permeability and retentionn(EPR) effect. With the PTT, the growth of cancer cells (MDA-MB-231ncells) can be remarkably ablated in vitro and in vivo; meanwhile nonobvious damage and noticeable toxicity are detected to major organs.nThe antitumor mechanism of Bi@DLPC NPs is attributable to the mitochondrialndysfunction and change of cell membrane permeability of MDA-MB-231ncells caused by photothermal effects upon laser irradiation. On thenbasis of their high stability and excellent biocompatibility, Bi@DLPCnNPs have great potential for the treatment of various types of tumors.","PeriodicalId":523091,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147909529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}