Figshare最新文献

筛选
英文 中文
Multifunctional Bismuth Nanoparticles as TheranosticnAgent for PA/CT Imaging and NIR Laser-Driven Photothermal Therapy 多功能铋纳米颗粒在PA/CT成像和近红外激光驱动光热治疗中的应用
Figshare Pub Date : 2018-02-08 DOI: 10.1021/acsanm.7b00255.s001
Chunyu Yang (269294), Chongshen Guo (1966351), Wei Guo (86150), Xiaole Zhao (2603575), Shaoqin Liu (1694335), Xiaojun Han (1653919)
{"title":"Multifunctional Bismuth Nanoparticles as TheranosticnAgent for PA/CT Imaging and NIR Laser-Driven Photothermal Therapy","authors":"Chunyu Yang (269294), Chongshen Guo (1966351), Wei Guo (86150), Xiaole Zhao (2603575), Shaoqin Liu (1694335), Xiaojun Han (1653919)","doi":"10.1021/acsanm.7b00255.s001","DOIUrl":"https://doi.org/10.1021/acsanm.7b00255.s001","url":null,"abstract":"“One-for-all”nmultifunctional theranostic agentsnare highly demanded in biomedical fields. However, their design andnfabrication still face enormous challenges. Herein, we strategicallyndesign and fabricate 1,2-dilauroyl-<i>sn</i>-glycero-3-phosphocholine-modifiedn(DLPC-modified) bismuth nanoparticles (denoted as Bi@DLPC NPs) withndesirable size of 47 ± 3 nm as a theranostic agent for photoacousticn(PA) and X-ray computed tomography (CT) imaging guided photothermalntherapy (PTT) in response to near-infrared (NIR) laser irradiation.nBi@DLPC NPs possess the excellent photothermal conversion efficiencynof 35% and PA/CT imaging properties, which are attributed to the strongnNIR absorption and high atomic number (83) of bismuth element. Moreover,nit is demonstrated that Bi@DLPC NPs are effectively accumulated innthe tumor region because of the enhanced permeability and retentionn(EPR) effect. With the PTT, the growth of cancer cells (MDA-MB-231ncells) can be remarkably ablated in vitro and in vivo; meanwhile nonobvious damage and noticeable toxicity are detected to major organs.nThe antitumor mechanism of Bi@DLPC NPs is attributable to the mitochondrialndysfunction and change of cell membrane permeability of MDA-MB-231ncells caused by photothermal effects upon laser irradiation. On thenbasis of their high stability and excellent biocompatibility, Bi@DLPCnNPs have great potential for the treatment of various types of tumors.","PeriodicalId":523091,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147909529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书