Figshare最新文献

筛选
英文 中文
Synergynof Nanotopography and Electrical Conductivitynof PEDOT/PSS for Enhanced Neuronal Development 协同,而不是纳米形貌和电导率,而不是PEDOT/PSS增强神经元发育
Figshare Pub Date : 2023-12-13 DOI: 10.1021/acsami.3c15278.s003
Michele Bianchi (2129686), Sonia Guzzo (7379435), Alice Lunghi (17628512), Pierpaolo Greco (2407132), Alessandra Pisciotta (117491), Mauro Murgia (1567390), Gianluca Carnevale (117495), Luciano Fadiga (41646), Fabio Biscarini (1302546)
{"title":"Synergynof Nanotopography and Electrical Conductivitynof PEDOT/PSS for Enhanced Neuronal Development","authors":"Michele Bianchi (2129686), Sonia Guzzo (7379435), Alice Lunghi (17628512), Pierpaolo Greco (2407132), Alessandra Pisciotta (117491), Mauro Murgia (1567390), Gianluca Carnevale (117495), Luciano Fadiga (41646), Fabio Biscarini (1302546)","doi":"10.1021/acsami.3c15278.s003","DOIUrl":"https://doi.org/10.1021/acsami.3c15278.s003","url":null,"abstract":"Biomaterials ablento promote neuronal development and neurite outgrowthnare highly desired in neural tissue engineering for the repair ofndamaged or disrupted neural tissue and restoring the axonal connection.nFor this purpose, the use of either electroactive or micro- and nanostructurednmaterials has been separately investigated. Here, the use of a nanomodulatednconductive poly­(3,4-ethylendioxithiophene) poly­(styrenesulfonate)n(PEDOT/PSS) substrate that exhibits instructive topographical andnelectrical cues at the same time was investigated for the first time.nIn particular, thin films featuring grooves with sizes comparablenwith those of neuronal neurites (NanoPEDOT) were fabricated by electrochemicalnpolymerization of PEDOT/PSS on a nanomodulated polycarbonate template.nThe ability of NanoPEDOT to support neuronal development and directnneurite outgrowth was demonstrated by assessing cell viability andnproliferation, expression of neuronal markers, average neurite length,nand direction of neuroblastoma N2A cells induced to differentiatenon this novel support. In addition to the beneficial effect of thennanogrooved topography, a 30% increase was shown in the average lengthnof neurites when differentiating cells were subjected to an electricalnstimulation of a few microamperes for 6 h. The results reported herensuggest a favorable effect on the neuronal development of the synergisticncombination of nanotopography and electrical stimulation, supportingnthe use of NanoPEDOT in neural tissue engineering to promote physicalnand functional reconnection of impaired neural networks.","PeriodicalId":522982,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147907526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书