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Genipin Analogue (G300) Inhibits Adipogenic Differentiationnof Human Bone Marrow-Derived Mesenchymal Stem Cells through the Suppressionnof Adipogenic Promoting Factors Genipin类似物（G300）通过抑制成脂促进因子抑制人骨髓间充质干细胞成脂分化

Figshare Pub Date : 2023-05-03 DOI: 10.1021/acs.jnatprod.3c00143.s001

Nittaya Boonmuen (3946631), Kanoknetr Suksen (1965403), Mintra Kaewkittikhun (15405060), Laongthip Ruknarong (15405063), Patamawadee Silalai (13008122), Rungnapha Saeeng (2686342), Arthit Chairoungdua (482766), Sunhapas Soodvilai (388059), Duangrat Tantikanlayaporn (482763)

{"title":"Genipin Analogue (G300) Inhibits Adipogenic Differentiationnof Human Bone Marrow-Derived Mesenchymal Stem Cells through the Suppressionnof Adipogenic Promoting Factors","authors":"Nittaya Boonmuen (3946631), Kanoknetr Suksen (1965403), Mintra Kaewkittikhun (15405060), Laongthip Ruknarong (15405063), Patamawadee Silalai (13008122), Rungnapha Saeeng (2686342), Arthit Chairoungdua (482766), Sunhapas Soodvilai (388059), Duangrat Tantikanlayaporn (482763)","doi":"10.1021/acs.jnatprod.3c00143.s001","DOIUrl":"https://doi.org/10.1021/acs.jnatprod.3c00143.s001","url":null,"abstract":"While obesity is a well-known healthnthreatening condition worldwide,neffective pharmacological interventions for obesity suppression havenbeen limited due to adverse effects. Therefore, it is important tonexplore alternative medical treatments for combating obesity. Inhibitionnof the adipogenesis process and lipid accumulation are critical targetsnfor controlling and treating obesity. <i>Gardenia jasminoides</i> Ellis is a traditional herbal remedy for various ailments. A naturalnproduct from its fruit, genipin, has major pharmacological properties;nit is anti-inflammatory and antidiabetic. We investigated the effectsnof a genipin analogue, G300, on adipogenic differentiation in humannbone marrow mesenchymal stem cells (hBM-MSCs). G300 suppressed thenexpression of adipogenic marker genes and adipokines secreted by adipocytesnat concentrations of 10 and 20 μM, which effectively reducednthe adipogenic differentiation of hBM-MSCs and lipid accumulationnin adipocytes. It also improved adipocyte function by lowering inflammatoryncytokine secretion and increasing glucose uptake. For the first time,nwe show that G300 has the potential to be a novel therapeutic agentnfor the treatment of obesity and its related disorders.","PeriodicalId":522883,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147905354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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