FigsharePub Date : 1753-01-01DOI: 10.1021/acs.joc.4c01895.s001
Iker Hernández (14381003), Guillermo Domínguez (20179319), Vadim A. Soloshonok (1367481), Aitor Landa (2130454), Mikel Oiarbide (1699942)
{"title":"Ynone Promoted DeaminativenCoupling of Gramines with <i>C</i>- and <i>N</i>‑Nucleophiles","authors":"Iker Hernández (14381003), Guillermo Domínguez (20179319), Vadim A. Soloshonok (1367481), Aitor Landa (2130454), Mikel Oiarbide (1699942)","doi":"10.1021/acs.joc.4c01895.s001","DOIUrl":"https://doi.org/10.1021/acs.joc.4c01895.s001","url":null,"abstract":"Thendeaminative coupling of gramines with nucleophiles representsna versatile approach for structure diversification, but often involvesnnon innocent conditions and/or reagents. Here a new acetylenic reagent <b>2</b> is developed for the C–N bond activation of graminesnand their in situ coupling with <i>C</i>- and <i>N</i>-centered nucleophiles. Using the new acid/base- and redox-neutralnynone reagent <b>2</b> the coupling reactions proceed exceedinglynas exemplified by the synthesis of several indol-3-ylmethyl derivatives,nincluding new indole-benzodiazepine and indole-hydrazone conjugates.","PeriodicalId":522787,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1753-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147903678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}