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Size-DependentnEffect of Titania Nanotubes on EndoplasmicnReticulum Stress to Re-establish Diabetic Macrophages Homeostasis 纳米钛管对糖尿病巨噬细胞内质网应激的影响

Figshare Pub Date : 2024-06-11 DOI: 10.1021/acsbiomaterials.4c00549.s001

Xiaoran Yu (6875402), Ruogu Xu (8834711), Xiaoqiong Huang (3091149), Hongcheng Chen (18804267), Zhengchuan Zhang (8834708), Iohong Wong (18804270), Zetao Chen (1829095), Feilong Deng (3223320)

{"title":"Size-DependentnEffect of Titania Nanotubes on EndoplasmicnReticulum Stress to Re-establish Diabetic Macrophages Homeostasis","authors":"Xiaoran Yu (6875402), Ruogu Xu (8834711), Xiaoqiong Huang (3091149), Hongcheng Chen (18804267), Zhengchuan Zhang (8834708), Iohong Wong (18804270), Zetao Chen (1829095), Feilong Deng (3223320)","doi":"10.1021/acsbiomaterials.4c00549.s001","DOIUrl":"https://doi.org/10.1021/acsbiomaterials.4c00549.s001","url":null,"abstract":"In patients with diabetes, endoplasmic reticulum stressn(ERS) isna crucial disrupting factor of macrophage homeostasis surroundingnimplants, which remains an obstacle to oral implantation success.nNotably, the ERS might be modulated by the implant surface morphology.nTitania nanotubes (TNTs) may enhance diabetic osseointegration. However,na consensus has not been achieved regarding the tube-size-dependentneffect and the underlying mechanism of TNTs on diabetic macrophagenERS. We manufactured TNTs with small (30 nm) and large diameters (100nnm). Next, we assessed how the different titanium surfaces affectedndiabetic macrophages and regulated ERS and Ca2+ homeostasis.nTNTs alleviated the inflammatory response, oxidative stress, and ERSnin diabetic macrophages. Furthermore, TNT30 was superior to TNT100.nInhibiting ERS abolished the positive effect of TNT30. Mechanistically,ntopography-induced extracellular Ca2+ influx might mitigatenexcessive ERS in macrophages by alleviating ER Ca2+ depletionnand IP3R activation. Furthermore, TNT30 attenuated the peri-implantninflammatory response and promoted osseointegration in diabetic rats.nTNTs with small nanodiameters attenuated ERS and re-established diabeticnmacrophage hemostasis by inhibiting IP3R-induced ER Ca2+ depletion.","PeriodicalId":522782,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147903541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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