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Allicin Alleviates Mitochondrial Dysfunction in Acrylamide-InducednRat Kidney Involving the Regulation of SIRT1 大蒜素通过调节SIRT1减轻丙烯酰胺诱导的大鼠肾脏线粒体功能障碍

Figshare Pub Date : 2023-10-13 DOI: 10.1021/acs.jafc.3c04687.s001

Lu Li (14069), Ziyue Wang (4595770), Yucai Li (10819451), Fuying Ma (4420600), Xinwei Wang (352488), Haiyang Yan (1422373), Wenliang Li (187808), Yong Pang (284282), Yuan Yuan (25702)

{"title":"Allicin Alleviates Mitochondrial Dysfunction in Acrylamide-InducednRat Kidney Involving the Regulation of SIRT1","authors":"Lu Li (14069), Ziyue Wang (4595770), Yucai Li (10819451), Fuying Ma (4420600), Xinwei Wang (352488), Haiyang Yan (1422373), Wenliang Li (187808), Yong Pang (284282), Yuan Yuan (25702)","doi":"10.1021/acs.jafc.3c04687.s001","DOIUrl":"https://doi.org/10.1021/acs.jafc.3c04687.s001","url":null,"abstract":"Acrylamide (AA), commonly formednin carbohydrate-rich thermallynprocessed foods, exerts harmful effects on the kidney. Allicin, fromncrushed garlic cloves, exhibits strong biological activities. In thencurrent study, the protection mechanisms of allicin against AA-causednnephrotoxicity were comprehensively examined using an <i>in vivo</i> rat model based on previous research that allicin plays a key rolenin improving renal function. The results showed that allicin attenuatednhistological changes of the kidney and ameliorated renal function.nDamaged mitochondrial structures, upregulated voltage-dependent anionnchannel 1 expression, and decreased membrane potential and adenosinen5′-triphosphate levels were observed after AA treatment. Surprisingly,nallicin notably reversed the adverse effects. Further, allicin effectivelynrestored mitochondrial function via modulating mitochondrial biogenesisnand dynamics, which might be associated with the upregulated expressionnof sirtuin 1 (SIRT1). Meanwhile, allicin dramatically activated thenSIRT1 activity and subsequently inhibited p53 acetylation, preventednthe translocation of cytochrome <i>c</i> to the cytoplasm,nand reduced the caspase expression, thus further inhibiting mitochondrialnapoptosis caused by AA. In summary, the relieving effect of allicinnon AA-caused nephrotoxicity lies in its inhibition of mitochondrialndysfunction and mitochondrial apoptosis.","PeriodicalId":522767,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147903237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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