FigsharePub Date : 2023-11-15DOI: 10.1021/acs.jnatprod.3c00664.s001
Minghua Jiang (6427763), Qilin Wu (9956363), Heng Guo (215190), Xin Lu (24821), Shuihao Chen (16324034), Lan Liu (88052), Senhua Chen (2544070)
{"title":"Shikimate-DerivednMeroterpenoids from the Ascidian-DerivednFungus <i>Amphichorda felina</i> SYSU-MS7908 and Their Anti-GliomanActivity","authors":"Minghua Jiang (6427763), Qilin Wu (9956363), Heng Guo (215190), Xin Lu (24821), Shuihao Chen (16324034), Lan Liu (88052), Senhua Chen (2544070)","doi":"10.1021/acs.jnatprod.3c00664.s001","DOIUrl":"https://doi.org/10.1021/acs.jnatprod.3c00664.s001","url":null,"abstract":"Gliomanis a clinically heterogeneous type of brain tumor with anpoor prognosis. Current treatment approaches have limited effectivenessnin treating glioma, highlighting the need for novel drugs. One approachnis to explore marine natural products for their therapeutic potential.nIn this study, we isolated nine shikimate-derived diisoprenyl-cyclohexene/ane-typenmeroterpenoids (<b>1</b>–<b>9</b>), including fournnew ones, amphicordins A–D (<b>1</b>–<b>4</b>) from the ascidian-derived fungus <i>Amphichorda felina</i> SYSU-MS7908, and further semisynthesized four derivatives (<b>10</b>–<b>13</b>). Their structures were extensivelyncharacterized using 1D and 2D NMR, modified Mosher’s method,nHR-ESIMS, NMR and ECD calculations, and X-ray crystallography. Notably,namphicordin C (<b>3</b>) possesses a unique benzo[<i>g</i>]chromene (6/6/6) skeleton in this meroterpenoid family. In an anti-gliomanassay, oxirapentyn A (<b>7</b>) effectively inhibited the proliferation,nmigration, and invasion of glioma cells and induced their apoptosis.nFurthermore, an <i>in silico</i> analysis suggested thatnoxirapentyn A has the potential to penetrate the blood–brainnbarrier. These findings highlight the potential of oxirapentyn A asna candidate for the development of novel anti-glioma drugs.","PeriodicalId":522657,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147901153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}