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Simple Fluorescence Turn-On Chemosensor for SelectivenDetection of Ba2+ Ion and Its Live Cell Imaging 用于选择性检测Ba&lt；sup>2+</sup&gt；离子的简单荧光开启化学传感器及其活细胞成像

Figshare Pub Date : 2019-06-28 DOI: 10.1021/acs.analchem.9b02057.s001

Palanisamy Ravichandiran (6941549), Sivakumar Allur Subramaniyan (5918975), Antony Paulraj Bella (6941552), Princy Merlin Johnson (6941555), Ae Rhan Kim (4019567), Kwan Seob Shim (6941558), Dong Jin Yoo (2717929)

{"title":"Simple Fluorescence Turn-On Chemosensor for SelectivenDetection of Ba2+ Ion and Its Live Cell Imaging","authors":"Palanisamy Ravichandiran (6941549), Sivakumar Allur Subramaniyan (5918975), Antony Paulraj Bella (6941552), Princy Merlin Johnson (6941555), Ae Rhan Kim (4019567), Kwan Seob Shim (6941558), Dong Jin Yoo (2717929)","doi":"10.1021/acs.analchem.9b02057.s001","DOIUrl":"https://doi.org/10.1021/acs.analchem.9b02057.s001","url":null,"abstract":"A phenoxazine-basednfluorescence chemosensor 4PB [(4-(tert-butyl)-N-(4-((4-((5-oxo-5H-benzo[a]phenoxazin-6-yl)amino)phenyl)sulfonyl)phenyl)benzamide)]nwas designed and synthesized by a simple synthetic methods. The 4PB fluorescence chemosensor selectively detects Ba2+ in the existence of other alkaline metal ions. In addition, 4PB showed high selectivity and sensitivity for Ba2+ detection. The detection limit of 4PB was 0.282 μMnand the binding constant was 1.0 × 106 M–1 in CH3CN/H2O (97.5:2.5 v/v, HEPES = 1.25 mM,npH 7.3) medium. This chemosensor functioned through the intramolecularncharge transfer (ICT) mechanism, which was further confirmed by DFTnstudies. Live cell imaging in MCF-7 cells confirmed the cell permeabilitynof 4PB and its capability for specific detection of Ba2+ in living cells.","PeriodicalId":522597,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147899919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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