Figshare最新文献

筛选

英文中文

Aggregation-Induced Emission Luminogen Assisted Self-Assemblynand Morphology Transition of Amphiphilic Glycopolypeptide with BioimagingnApplication 聚集诱导发射发光材料辅助两亲性甘共肽自组装和形态转变及其生物成像应用

Figshare Pub Date : 2019-07-12 DOI: 10.1021/acsmacrolett.9b00383.s001

Huaijun Chen (4612255), Ensong Zhang (6948905), Guang Yang (154978), Long Li (6555), Libin Wu (2238538), Yufei Zhang (509147), Yijiang Liu (1463026), Guosong Chen (1397413), Ming Jiang (11433)

{"title":"Aggregation-Induced Emission Luminogen Assisted Self-Assemblynand Morphology Transition of Amphiphilic Glycopolypeptide with BioimagingnApplication","authors":"Huaijun Chen (4612255), Ensong Zhang (6948905), Guang Yang (154978), Long Li (6555), Libin Wu (2238538), Yufei Zhang (509147), Yijiang Liu (1463026), Guosong Chen (1397413), Ming Jiang (11433)","doi":"10.1021/acsmacrolett.9b00383.s001","DOIUrl":"https://doi.org/10.1021/acsmacrolett.9b00383.s001","url":null,"abstract":"Recently, fluorescentnmacromolecules with AIE effect have attractednconsiderable attentions due to their remarkable optical properties.nIn particular, designing novel tetraphenylethylene (TPE)-based bioconjugatesnto construct various self-assembled nanostructures and to expand thenapplications have aroused great interests. Herein, we report the self-assemblynof TPE-based amphiphilic glycopolypeptide bioconjugate for bioimagingnand tracing of live cells. The resultant amphiphilic fluorescent glycopolypeptidenP1tM-TPE could self-assemble into different nanostructures, includingnvesicles, spindles and porous nanosheets, which mainly depends onnthe water fraction in DMSO/water mixture. At the same time, the vesiclesncan transform to spindles when increasing the water fractions. Bothnthe vesicles and spindles are prone to be effectively internalizednby macrophages, and all of them performed outstanding intracellularnfluorescent retention properties. As far as we know, this is the firstnreport on self-assembly and applications of glycopolypeptide–TPEnbioconjugate, which will deepen our understanding on the self-assemblynmechanism of TPE-based bioconjugates and provide a new way for fabricatingnfunctional fluorescent materials to monitor various biological processes.","PeriodicalId":522584,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147899720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0