FigsharePub Date : 2018-02-16DOI: 10.1021/acs.joc.7b03182.s002
Jia-Wang Liu (4858354), Ming-Yu Zhang (2089123), Yong-Ming Yan (1633354), Xiao-Yi Wei (1633357), Lu Dong (741219), Yan-Xia Zhu (4858351), Yong-Xian Cheng (348615)
{"title":"Characterization ofnSesquiterpene Dimers from <i>Resina Commiphora</i> ThatnPromote Adipose-Derived Stem CellnProliferation and Differentiation","authors":"Jia-Wang Liu (4858354), Ming-Yu Zhang (2089123), Yong-Ming Yan (1633354), Xiao-Yi Wei (1633357), Lu Dong (741219), Yan-Xia Zhu (4858351), Yong-Xian Cheng (348615)","doi":"10.1021/acs.joc.7b03182.s002","DOIUrl":"https://doi.org/10.1021/acs.joc.7b03182.s002","url":null,"abstract":"The new sesquiterpene dimers commiphoroidsnA–D (<b>1</b>–<b>4</b>) were isolated from <i>Resina Commiphora</i>, and their structures were assigned bynspectroscopic methods andnX-ray diffraction analysis. Compounds <b>1</b> and <b>2</b> are stereoisomers of putative [2 + 4]-cycloaddition reactions, and <b>3</b> is a trinorsesquiterpene dimer containing a 6/6/5/6/6/6nhexacyclic framework, while <b>4</b> possesses a 8-oxabicyclo[3.2.1]oct-6-enenskeletal core. Plausible biosynthetic pathways for <b>1</b>–<b>4</b> are proposed. Biochemical studies show that compound <b>1</b> promotes ca. 60% expression of keratinocyte-specific markersnin adipose-derived stem cells at 10 μM.","PeriodicalId":522483,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147897919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}