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New Insights into DecabromodiphenylnEther-Induced Splenic Injury in Chickens: Involvementnof ROS-Mediated Endoplasmic Reticulum Stress Pathway Triggering Autophagynand Apoptosis 十溴联苯内酰胺诱导鸡脾损伤的新认识：参与非ros介导的内质网应激通路触发自噬和细胞凋亡

Figshare Pub Date : 2024-02-10 DOI: 10.1021/acs.jafc.3c09104.s001

Bendong Shi (17943986), Bowen Dong (8973263), Jianhua Shan (17943989), Zhuoqi Zhang (2611912), Qiaohan Liu (17943992), Yangyang Jiang (2498965), Cheng Fang (611972), Jingzeng Cai (17943995), Ziwei Zhang (2029975)

{"title":"New Insights into DecabromodiphenylnEther-Induced Splenic Injury in Chickens: Involvementnof ROS-Mediated Endoplasmic Reticulum Stress Pathway Triggering Autophagynand Apoptosis","authors":"Bendong Shi (17943986), Bowen Dong (8973263), Jianhua Shan (17943989), Zhuoqi Zhang (2611912), Qiaohan Liu (17943992), Yangyang Jiang (2498965), Cheng Fang (611972), Jingzeng Cai (17943995), Ziwei Zhang (2029975)","doi":"10.1021/acs.jafc.3c09104.s001","DOIUrl":"https://doi.org/10.1021/acs.jafc.3c09104.s001","url":null,"abstract":"Decabromodiphenylnether (BDE-209) is a widely used brominated flamenretardant that can easily detach from materials and enter into feednand foodstuffs, posing a serious risk to human and animal health andnfood safety of animal origin. However, the immunotoxic effects ofnBDE-209 on the avian spleen and the exact mechanism of the toxicitynremain unknown. Therefore, we established an experimental model ofnBDE-209-exposed chickens and a positive control model of cyclophosphamide-inducednimmunosuppression in vivo and treated MDCC-MSB-1 cells and chickennsplenic primary lymphocytes with BDE-209 in vitro. The results showednthat BDE-209 treatment caused morphological and structural abnormalitiesnin the chicken spleens. Mechanistically, indicators related to oxidativenstress, endoplasmic reticulum stress (ERS), autophagy, and apoptosisnwere significantly altered by BDE-209 exposure in both the spleennand lymphocytes, but the use of the <i>N</i>-acetylcysteinenor the 4-phenylbutyric acid significantly reversed these changes.nIn addition, BDE-209 exposure decreased the spleen antimicrobial peptidenand immunoglobulin gene expression. In conclusion, the present researchnrevealed that BDE-209 exposure enhanced lymphocyte autophagy and apoptosisnin chicken spleen via the ROS-mediated ERS pathway. This signalingncascade regulatory relationship not only opens up a new avenue fornstudying BDE-209 immunotoxicity but also provides important insightsninto preventing BDE-209 hazards to animal health.","PeriodicalId":522384,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147896144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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