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Target-Binding Accelerated Response for SensitivenDetection of Basal H2O2 in Tumor Cells and Tissuesnvia a Dual-Functional Fluorescence Probe 双功能荧光探针检测肿瘤细胞和组织中基底H&lt；sub>2O2</sub&gt

Figshare Pub Date : 1753-01-01 DOI: 10.1021/acs.analchem.2c00400.s001

Mingxiu Wang (346706), Feng Zhang (6548), Cai-Qi Wang (12355030), Nan Yin (9420956), Yuting Wang (434390), Guixin Qin (9958964), Qingling Xu (1878283), Jianhua Gong (530290), Huizhen Liu (1596664), Xinrui Duan (1481911)

{"title":"Target-Binding Accelerated Response for SensitivenDetection of Basal H2O2 in Tumor Cells and Tissuesnvia a Dual-Functional Fluorescence Probe","authors":"Mingxiu Wang (346706), Feng Zhang (6548), Cai-Qi Wang (12355030), Nan Yin (9420956), Yuting Wang (434390), Guixin Qin (9958964), Qingling Xu (1878283), Jianhua Gong (530290), Huizhen Liu (1596664), Xinrui Duan (1481911)","doi":"10.1021/acs.analchem.2c00400.s001","DOIUrl":"https://doi.org/10.1021/acs.analchem.2c00400.s001","url":null,"abstract":"Aberrantnproduction of H2O2 is involved inncancer. The levels of H2O2 are significantlynhigher in tumor cells than in normal cells. It is important to developnfluorescent probes to image basal H2O2 selectivelynin tumor cells. So far, a cancer cell-targeting probe to image basalnH2O2 has not been reported. Thus, we developedna fluorescent probe, BBHP, which contains benzil as anH2O2-recognition site and biotin as a targetnbinding motif for the selective and sufficient detection of H2O2 in tumor cells. BBHP enables anselective fluorescence turn-on response to H2O2. The binding of the probe with biotin receptors can greatly acceleratenthe fluorescence response to H2O2. As a result, BBHP can sufficiently image basal H2O2 in biotin receptor-positive cancer cells and tumor tissues. Finally, BBHP was successfully applied to discriminate between cancerousnand normal tissues.","PeriodicalId":522307,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1753-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147894957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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