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Multifunctionaln“Add-On”nModule EnablednNIR-II Imaging-Guided Synergistic Photothermal and Chemotherapy ofnDrug-Resistant Lung Cancer 多功能n“附加”n模块支持 nir - ii成像引导协同光热和化疗n耐药肺癌

Figshare Pub Date : 2024-11-29 DOI: 10.1021/acsami.4c14519.s001

Yu Li (183836), Qiang Zhu (188733), Pei He (836326), Tingjuan Wu (148258), Zhen Ouyang (351683), Lijun Zhu (1811353), Fang Wang (105926), Xin Zhou (54275), Zhong-Xing Jiang (1393318), Shizhen Chen (1608298)

{"title":"Multifunctionaln“Add-On”nModule EnablednNIR-II Imaging-Guided Synergistic Photothermal and Chemotherapy ofnDrug-Resistant Lung Cancer","authors":"Yu Li (183836), Qiang Zhu (188733), Pei He (836326), Tingjuan Wu (148258), Zhen Ouyang (351683), Lijun Zhu (1811353), Fang Wang (105926), Xin Zhou (54275), Zhong-Xing Jiang (1393318), Shizhen Chen (1608298)","doi":"10.1021/acsami.4c14519.s001","DOIUrl":"https://doi.org/10.1021/acsami.4c14519.s001","url":null,"abstract":"Imaging-guided chemo-photothermalncombination therapyn(chemo-PTT)nis recognized for its synergistic therapeutic effects, reduced sideneffects, and minimal drug resistance, while the development of suchntheranostics has been hampered by poor imaging and therapy performancenand tedious formulation. Herein, we introduce an all-in-one “add-on”nmodule (BBT-C6) for the convenient construction of doxorubicinn(DOX)-loaded nanoparticles (DOX@BBT) and efficient second near-infraredn(NIR-II) fluorescence imaging (FLI)-guided synergistic chemo-PTT ofndrug-resistant lung cancer. The delicate Janus amphiphilic structurenof BBT-C6 enables multifunctionality, including NIR-IInFLI, aggregation-induced emission (AIE) characteristics, moderatenphotothermal conversion efficiency (PCE), excellent photostability,nand polyethylene glycolation (PEGylation), which could improve thenNIR-II FLI and PTT performance, relieve the complexity in theranostics,nand enable high reproducibility of the multifunctional theranostics.nConfocal microscopy revealed that BBT@DOX efficientlyndelivers DOX into cells, resulting in an increased accumulation ofnDOX that exceeds the efflux capacity of DOX-resistant cells. Bothnin vitro and in vivo studies demonstrate that BBT-C6 enhancesnthe effectiveness of BBT@DOX, achieving highly effectivenphotothermal-chemo synergistic therapy against DOX-resistant lungncancer. Beyond developing a versatile “add-on” modulenfor conveniently constructing multifunctional nanosystems, this studynprovides new insights into the design of advanced theranostics fornprecise biomedical applications.","PeriodicalId":522201,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147893324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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