{"title":"Tissue-Adhesive Decellularized Extracellular MatrixnPatches Reinforced by a Supramolecular Gelator to Repair AbdominalnWall Defects","authors":"Akihiro Nishiguchi (1532491), Shima Ito (13851821), Kazuhiro Nagasaka (13851824), Tetsushi Taguchi (1495435)","doi":"10.1021/acs.biomac.2c01210.s001","DOIUrl":"https://doi.org/10.1021/acs.biomac.2c01210.s001","url":null,"abstract":"Implantationnof surgical meshes composed of synthetic and biologicalnmaterials has been applied for abdominal wall defect repair. Despitenmany efforts, there are no reliable meshes that fully satisfy clinicalnrequirements because of their lack of biodegradability, mechanicalnstrength, and tissue-adhesive properties. Here, we report biodegradable,ndecellularized extracellular matrix (dECM)-based biological patchesnto treat abdominal wall defects. By incorporating a water-insolublensupramolecular gelator that forms physical cross-linking networksnthrough intermolecular hydrogen bonding, dECM patches were reinforcednto improve mechanical strength. Reinforced dECM patches possessednhigher tissue adhesion strength and underwater stability comparednwith the original dECM because of enhanced interfacial adhesion strength.nIn vivo experiments using an abdominal wall defect rat model showednthat reinforced dECM patches induced collagen deposition and the formationnof blood vessels during material degradation, and the accumulationnof CD68-positive macrophages was suppressed compared to nonbiodegradablensynthetic meshes. Tissue-adhesive and biodegradable dECM patches withnimproved mechanical strength by a supramolecular gelator have enormousnpotential for use in the repair of abdominal wall defects.","PeriodicalId":522180,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147893017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}