FigsharePub Date : 2024-11-14DOI: 10.1021/acs.langmuir.4c03206.s001
Xu Zhang (49484), Yinghao Liu (4767039), Xue’e Zhang (20205671), Mengzhen Tang (20205674), Weihong Xi (20205677), Junchao Wei (625086)
{"title":"AntimicrobialnGL13K Peptide-Decorated ZnO NanoparticlesnTo Treat Bacterial Infections","authors":"Xu Zhang (49484), Yinghao Liu (4767039), Xue’e Zhang (20205671), Mengzhen Tang (20205674), Weihong Xi (20205677), Junchao Wei (625086)","doi":"10.1021/acs.langmuir.4c03206.s001","DOIUrl":"https://doi.org/10.1021/acs.langmuir.4c03206.s001","url":null,"abstract":"As a broad-spectrum antimicrobialnmaterial, ZnO nanoparticles (NPs)noffer a novel approach to infected wounds in the clinic; however,nit is very necessary to improve the antimicrobial performance of ZnOnto satisfy the clinic requirements. In this work, a new antimicrobialnhybrid ZnO@PDA/GL13K was prepared by attaching the antimicrobial GL13Knpeptide on the surface of ZnO NPs via polydopamine (PDA) as a covalentnbonding agent, which can enhance the reactive oxygen species (ROS)nproduction and damage the cell wall, showing superior antimicrobialnefficacy. Besides, the ZnO@PDA/GL13K hybrid can promote the healingnof bacterial infected wounds, with the wound area only remaining 1.8%non day 9, about 2 times smaller than that of the ZnO group. Moreover,nZnO@PDA/GL13K also showed good biocompatibility, and no side effectnon normal tissue and organs was found, implying that the antimicrobialnhybrid may possess prospective application in biomedical fields.","PeriodicalId":522175,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147892928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}