FigsharePub Date : 2018-08-06DOI: 10.1021/acs.molpharmaceut.8b00473.s001
Qi Li (67548), Yilin Chen (678552), Xinyi Zhou (3594002), Dengyue Chen (4459597), Yang Li (7082), Jiayong Yang (5596844), Xuan Zhu (188226)
{"title":"Hyaluronic Acid–Methotrexate Conjugates CoatednMagnetic Polydopamine Nanoparticles for Multimodal Imaging-GuidednMultistage Targeted Chemo-Photothermal Therapy","authors":"Qi Li (67548), Yilin Chen (678552), Xinyi Zhou (3594002), Dengyue Chen (4459597), Yang Li (7082), Jiayong Yang (5596844), Xuan Zhu (188226)","doi":"10.1021/acs.molpharmaceut.8b00473.s001","DOIUrl":"https://doi.org/10.1021/acs.molpharmaceut.8b00473.s001","url":null,"abstract":"Combinationncancer therapy with various kinds of therapeutic approachesncould improve the effectiveness of treatment while reducing side effects.nHerein, we elaborately developed a theranostics nanoplatform basednon magnetic polydopamine (MPDA) coated with hyaluronic acid–methotrexatenconjugates (MPDA@HA–MTX) for chemo-photothermal treatment (PTT).nIn this nanoplatform, Fe<sub>3</sub>O<sub>4</sub> served as the corenwas applied as contrast agent for T<sub>2</sub>-weighted magneticnresonance imaging (MRI) and early phase magnet targeting. Meanwhile,nPDA was used as a versatile shell for effective loading of chemotherapeuticndoxorubicin (DOX) to achieve controlled release and PTT simultaneously.nMoreover, HA–MTX conjugates could offer later-phase specificncellular dual-targeting ability during the therapy. Both <i>innvitro</i> and <i>in vivo</i> studies demonstrated thatnDOX-loaded MPDA@HA–MTX (MPDA/DOX@HA–MTX) exhibited thenpreferential tumor accumulation, enhanced specificity to target tumorncells, pH-/laser-responsive release, and high tumor cell-killing efficiency.nBy combined chemo-PTT under the guidance of fluorescence/MR imaging,nthe tumors in mice were completely eliminated after treatment, indicatingnthat MPDA@HA–MTX nanoparticles have great potential as a novelndrug-loading platform for imaging-guided multistage targeted chemo-photothermalncombination therapy.","PeriodicalId":522149,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147892434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}