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Autophagy-DependentnApoptosis Induced by Apoferritin–Cu(II)nNanoparticles in Multidrug-Resistant Colon Cancer Cells 载铁蛋白- cu （II）纳米颗粒诱导多药耐药结肠癌细胞自噬依赖性凋亡

Figshare Pub Date : 2021-08-11 DOI: 10.1021/acsami.1c07223.s002

Kai Xiong (1688272), Ying Zhou (25031), Johannes Karges (7345259), Kejie Du (11262045), Jinchao Shen (11262048), Mingwei Lin (11262051), Fangmian Wei (11262054), Junfeng Kou (11262057), Yu Chen (29959), Liangnian Ji (1504423), Hui Chao (1504435)

{"title":"Autophagy-DependentnApoptosis Induced by Apoferritin–Cu(II)nNanoparticles in Multidrug-Resistant Colon Cancer Cells","authors":"Kai Xiong (1688272), Ying Zhou (25031), Johannes Karges (7345259), Kejie Du (11262045), Jinchao Shen (11262048), Mingwei Lin (11262051), Fangmian Wei (11262054), Junfeng Kou (11262057), Yu Chen (29959), Liangnian Ji (1504423), Hui Chao (1504435)","doi":"10.1021/acsami.1c07223.s002","DOIUrl":"https://doi.org/10.1021/acsami.1c07223.s002","url":null,"abstract":"Chemotherapyncontinues to be the most commonly applied strategynfor cancer. Despite the impressive clinical success obtained withnseveral drugs, increasing numbers of (multi)drug-resistant tumorsnare reported. To overcome this shortcoming, novel drug candidatesnand delivery systems are urgently needed. Herein, a therapeutic coppernpolypyridine complex encapsulated in natural nanocarrier apoferritinnis reported. The generated nanoparticles showed higher cytotoxicityntoward various (drug-resistant) cancer cell lines than noncancerousncells. The study of the mechanism revealed that the compound triggersncell autophagy-dependent apoptosis. Promisingly, upon injection ofnthe nanodrug conjugate into the bloodstream of a mouse model bearingna multidrug-resistant colon tumor, a strong tumor growth inhibitionneffect was observed. To date, this is the first study describing thenencapsulation of a copper complex in apoferritin that acts by autophagy-dependentnapoptosis.","PeriodicalId":522124,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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