FigsharePub Date : 2016-09-29DOI: 10.1021/acs.cgd.6b01284.s001
Yuqing Cui (1529068), Jelena Stojakovic (1308018), Hideomi Kijima (3127350), Allan S. Myerson (1444300)
{"title":"Mechanism of Contact-Induced Heterogeneous Nucleation","authors":"Yuqing Cui (1529068), Jelena Stojakovic (1308018), Hideomi Kijima (3127350), Allan S. Myerson (1444300)","doi":"10.1021/acs.cgd.6b01284.s001","DOIUrl":"https://doi.org/10.1021/acs.cgd.6b01284.s001","url":null,"abstract":"Understandingnand controlling nucleation is a long-standing issuenin the field of crystallization and solid state chemistry. Herein,nwe use gold–thiol self-assembled monolayers (SAMs) as heterosurfacesnin combination with contact force to induce nucleation. Our approachnelucidates the mechanism of contact-induced heterogeneous nucleationnand has clear technological implications in that it reduces inductionntime and controls polymorphism of pharmaceutical crystals. The combinationnof SAMs and contact force can immediately induce nucleation undernconditions that do not otherwise promote fast crystallization. Thenchance of nucleation is enhanced by SAMs that interact strongly withnsolute molecules. These observations and analyses of obtained crystalsnled us to conclude that contact-induced heterogeneous nucleation followsna similar path as undisturbed heterogeneous nucleation in the earlynstage, but departs from it at the later stage due to the interruptionnby contact force. In contrast to undisturbed heterogeneous nucleation,ncrystals are not attached to and do not chemically interact with SAMsnin contact-induced heterogeneous nucleation.","PeriodicalId":522080,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}