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Enhancing the AntitumornEfficacy of Oncolytic AdenovirusnThrough Sonodynamic Therapy-Augmented Virus Replication 通过声动力疗法增强病毒复制增强溶瘤腺病毒的抗肿瘤效果

Figshare Pub Date : 2024-07-02 DOI: 10.1021/acsnano.4c01115.s001

Junqiang Ding (819208), Runping Su (14248166), Rong Yang (107028), Jinliang Xu (8443134), Xiaoxiao Liu (671993), Tingting Yao (2554606), Sha Li (145229), Cong Wang (107450), Hanchang Zhang (2683531), Qi Yue (1970341), Changyou Zhan (483827), Cong Li (115171), Xihui Gao (1818739)

{"title":"Enhancing the AntitumornEfficacy of Oncolytic AdenovirusnThrough Sonodynamic Therapy-Augmented Virus Replication","authors":"Junqiang Ding (819208), Runping Su (14248166), Rong Yang (107028), Jinliang Xu (8443134), Xiaoxiao Liu (671993), Tingting Yao (2554606), Sha Li (145229), Cong Wang (107450), Hanchang Zhang (2683531), Qi Yue (1970341), Changyou Zhan (483827), Cong Li (115171), Xihui Gao (1818739)","doi":"10.1021/acsnano.4c01115.s001","DOIUrl":"https://doi.org/10.1021/acsnano.4c01115.s001","url":null,"abstract":"The therapeutic efficacy of oncolytic adenoviruses (OAs)nreliesnon efficient viral transduction and replication. However, the limitednexpression of coxsackie-adenovirus receptors in many tumors, alongnwith the intracellular antiviral signaling, poses significant obstaclesnto OA infection and oncolysis. Here, we present sonosensitizer-armednOAs (saOAs) that potentiate the antitumor efficacy of oncolytic virotherapynthrough sonodynamic therapy-augmented virus replication. The saOAsncould not only efficiently infect tumor cells <i>via</i> transferrin receptor-mediated endocytosis but also exhibit enhancednviral replication and tumor oncolysis under ultrasound irradiation.nWe revealed that the sonosensitizer loaded on the viruses inducednthe generation of ROS within tumor cells, which triggered JNK-mediatednautophagy, ultimately leading to the enhanced viral replication. Innmouse models of malignant melanoma, the combination of saOAs and sonodynamicntherapy elicited a robust antitumor immune response, resulting innsignificant inhibition of melanoma growth and improved host survival.nThis work highlights the potential of sonodynamic therapy in enhancingnthe effectiveness of OAs and provides a promising platform for fullynexploiting the antitumor efficacy of oncolytic virotherapy.","PeriodicalId":522072,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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