Figshare最新文献

筛选
英文 中文
Nanoassembliesnof Chitosan-Based Polyelectrolyte Complexesnas Nucleic Acid Delivery Systems 纳米组装体/壳聚糖基多电解质复合物/核酸递送系统
Figshare Pub Date : 2024-07-18 DOI: 10.1021/acs.biomac.4c00054.s001
HusseinH. Genedy (19170679), Thierry Delair (1944982), Pierre Alcouffe (1532404), Agnès Crépet (9375740), Elodie Chatre (19170682), Khair Alhareth (13362869), Alexandra Montembault (1944979)
{"title":"Nanoassembliesnof Chitosan-Based Polyelectrolyte Complexesnas Nucleic Acid Delivery Systems","authors":"HusseinH. Genedy (19170679), Thierry Delair (1944982), Pierre Alcouffe (1532404), Agnès Crépet (9375740), Elodie Chatre (19170682), Khair Alhareth (13362869), Alexandra Montembault (1944979)","doi":"10.1021/acs.biomac.4c00054.s001","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c00054.s001","url":null,"abstract":"Nucleic acid delivery requires vectorization for protectionnfromnnucleases, preventing clearance by the reticuloendothelial system,nand targeting to allow cellular uptake. Nanovectors meeting the abovenspecifications should be safe for the patient, simple to manufacture,nand display long-term stability. Our nanovectors were obtained vianthe green process of polyelectrolyte complexation, carried out atn25 °C in water at a low shear rate using chitosan (a polycationicnbiocompatible polysaccharide of specific molar mass and acetylationndegree) and dextran sulfate as a polyanionic biocompatible polysaccharide.nThese complexes formed nanoassemblies of primary nanoparticles (20–35nnm) and maintained their colloidal stability for over 1 year at 25n°C. They could be steam sterilized, and a model nucleic acidncould be either encapsulated or surface adsorbed. A targeting agentnwas finally bound to their surface. This work serves as a proof ofnconcept of the suitability of chitosan-based polyelectrolyte complexesnas nanovectors by sequential multilayered adsorption of various biomacromolecules.","PeriodicalId":522041,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147890327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书