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Magnesium-StabilizednMultifunctional DNA Nanoparticlesnfor Tumor-Targeted and pH-Responsive Drug Delivery 用于肿瘤靶向和ph反应药物递送的镁稳定多功能DNA纳米颗粒

Figshare Pub Date : 2018-04-30 DOI: 10.1021/acsami.8b01932.s001

Haoran Zhao (2656), Xuexia Yuan (5155304), Jiantao Yu (1639270), Yishun Huang (1628362), Chen Shao (175680), Fan Xiao (1422463), Li Lin (111038), Yan Li (23143), Leilei Tian (1995697)

{"title":"Magnesium-StabilizednMultifunctional DNA Nanoparticlesnfor Tumor-Targeted and pH-Responsive Drug Delivery","authors":"Haoran Zhao (2656), Xuexia Yuan (5155304), Jiantao Yu (1639270), Yishun Huang (1628362), Chen Shao (175680), Fan Xiao (1422463), Li Lin (111038), Yan Li (23143), Leilei Tian (1995697)","doi":"10.1021/acsami.8b01932.s001","DOIUrl":"https://doi.org/10.1021/acsami.8b01932.s001","url":null,"abstract":"Functional nucleicnacids, which can target cancer cells and realizenstimuli-responsive drug delivery in tumor microenvironment, have beennwidely applied for anticancer chemotherapy. At present, high cost,nunsatisfactory biostability, and complicated fabrication process arenthe main limits for the development of DNA-based drug-delivery nanocarriers.nHere, a doxorubicin (Dox)-delivery nanoparticle for tumor-targetingnchemotherapy is developed taking advantage of rolling circle amplificationn(RCA) technique, by which a high quantity of functional DNAs can benefficiently collected. Furthermore, Mg2+, a major electrolytenin human body showing superior biocompatibility, can sufficientlyncondense the very long sequence of an RCA product and better preservenits functions. The resultant DNA nanoparticle exhibits a high biostability,nmaking it a safe and ideal nanomaterial for in vivo application. Throughncellular and in vivo experiments, we thoroughly demonstrate that thisnkind of Mg2+-stabilized multifunctional DNA nanoparticlesncan successfully realize tumor-targeted Dox delivery. Overall, exploitingnRCA technique and Mg2+ condensation, this new strategyncan fabricate nanoparticles with a nontoxic composition through ansimple fabrication process and provides a good way to preserve andnpromote DNA functions, which will show a broad application potentialnin the biomedical field.","PeriodicalId":521978,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147888941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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