FigsharePub Date : 2024-04-18DOI: 10.1021/acs.jafc.3c08251.s001
Hongjuan Fu (6253046), Jianbo He (2037922), Cong Li (115171), Hui Chang (335446)
{"title":"Theaflavin-3,3'-DigallatenProtects Liver and KidneynFunctions in Diabetic Rats by Up-Regulating Circ-ITCH and Nrf2 SignalingnPathway","authors":"Hongjuan Fu (6253046), Jianbo He (2037922), Cong Li (115171), Hui Chang (335446)","doi":"10.1021/acs.jafc.3c08251.s001","DOIUrl":"https://doi.org/10.1021/acs.jafc.3c08251.s001","url":null,"abstract":"Theaflavin-3,3′-digallate (TFDG) in black teanhas a strongnantioxidant capacity. However, its effect on diabetic liver and kidneyninjury and the underlying mechanisms remain unclear. In the presentnstudy, our findings indicated that TFDG administration effectivelynlowers the fasting blood glucose and serum lipid concentrations andnenhances the functionality and cellular architecture of the livernand kidney in rats with diabetes. The data also showed that TFDG mitigatesnoxidative harm in the liver and kidney of rats afflicted with diabetes.nAdditionally, metformin combined with TFDG was significantly moreneffective in reducing blood glucose and oxidative stress. Furthernstudies suggested that TFDG upregulates the Nrf2 signal pathway andncirc-ITCH (hsa_circ_0001141) expression. Silencing of circ-ITCH byntransfection of the interfering plasmid apparently reduces the effectsnof TFDG on the Nrf2 signal pathway and oxidative stress in high-glucose-treatednhepatic and renal cells. In conclusion, the present study highlightsnthe great potential of TFDG in ameliorating diabetic liver and kidneyninjury by up-regulating circ-ITCH to promote the Nrf2 signal pathwaynand provides a potential option for the prevention and treatment ofndiabetic complications.","PeriodicalId":521909,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147887642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}