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Graphene Oxide/Chitosan/Hydroxyapatite Composite MembranesnEnhance Osteoblast Adhesion and Guided Bone Regeneration 氧化石墨烯/壳聚糖/羟基磷灰石复合膜增强成骨细胞粘附和引导骨再生

Figshare Pub Date : 2021-10-25 DOI: 10.1021/acsabm.1c00967.s001

Sudan Liu (11603829), Zirui Li (5738612), Qiuxiang Wang (4577653), Jing Han (43038), Wenying Wang (187565), Shenghui Li (432673), Huifang Liu (792239), Shutao Guo (1320417), Jinchao Zhang (1324296), Kun Ge (51792), Guoqiang Zhou (2074213)

{"title":"Graphene Oxide/Chitosan/Hydroxyapatite Composite MembranesnEnhance Osteoblast Adhesion and Guided Bone Regeneration","authors":"Sudan Liu (11603829), Zirui Li (5738612), Qiuxiang Wang (4577653), Jing Han (43038), Wenying Wang (187565), Shenghui Li (432673), Huifang Liu (792239), Shutao Guo (1320417), Jinchao Zhang (1324296), Kun Ge (51792), Guoqiang Zhou (2074213)","doi":"10.1021/acsabm.1c00967.s001","DOIUrl":"https://doi.org/10.1021/acsabm.1c00967.s001","url":null,"abstract":"Two-dimensionalnmaterials provide a secluded space for bone formationnand preserve the growth of surrounding tissues, thus playing a crucialnrole in guided bone regeneration (GBR). Graphene oxide (GO) has beennwidely employed in GBR due to its good mechanical and hydrophilicnproperties. A single GO membrane, however, does not provide a friendlynenvironment for osteogenic cell adhesion. With their adjustable mechanicalnproperties and excellent biocompatibility, composite membranes cannsimulate the multicomponent structure of an extracellular matrix forncell adhesion. To obtain two-dimensional membranes with appropriatenmechanical strength and sufficient biocompatibility, GO-based compositenmembranes simultaneously containing chitosan (CS) and hydroxyapatiten(HAP) were first prepared using one-step vacuum filtration and a biomimeticnmineralization method. CS and HAP improved the mechanical strengthnand surface hydrophilicity of the membranes. In addition, moderatenaddition of HAP enhanced the adhesion, differentiation, and mineralizationnof osteoblasts. The prepared composite membranes were then implantedninto a calvarial defect model to evaluate their osteogenic inductionneffects in vivo. Microcomputed tomography observation and histologicalnanalysis indicate that GO/CS/HAP composite membranes can acceleratenbone regeneration without the contribution of endogenous cytokines.nGO/CS/HAP composite membranes with unique biomimetic porous structures,nsuperior mechanical properties, and excellent bone regeneration capacitynare potential materials for application in GBR.","PeriodicalId":521640,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147883111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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