FigsharePub Date : 2024-05-08DOI: 10.1021/acsomega.3c10395.s001
Yuanyuan Li (18671), Dongjie Yang (356458), Sijia Wang (36816), Huifang Xu (111603), PengWei Li (6410738)
{"title":"Fabrication andnOptimization of Pickering EmulsionnStabilized by Lignin Nanoparticles for Curcumin Encapsulation","authors":"Yuanyuan Li (18671), Dongjie Yang (356458), Sijia Wang (36816), Huifang Xu (111603), PengWei Li (6410738)","doi":"10.1021/acsomega.3c10395.s001","DOIUrl":"https://doi.org/10.1021/acsomega.3c10395.s001","url":null,"abstract":"To develop reversible pH-responsive emulsifiers of naturalnorigin,nalkali lignin (AL) was used to develop oil-in-water Pickering emulsions.nAL was first modified to synthesize quaternized alkali lignin (QAL),nwhich displayed pH-responsive properties and demonstrated solubilitynin both acidic and alkaline solutions. In contrast, QAL exhibitedninsolubility and formed particles in neutral solutions, thereby makingnit a suitable candidate for utilization as an emulsifier in doublynpH-responsive Pickering emulsions. At pH 5–9, the emulsionsnwere stable. Above or below this pH range, the system demulsifies,nresulting in a reversible Pickering emulsifier with two pH-controlledntransitions. On the basis of this pH-dependent behavior, lignin-basednPickering emulsions (LPE) could be subjected to several cycles ofnemulsification–demulsification by alternating the pH of thenaqueous phase between basic and acidic, while the droplet size andnstorage stability were maintained. Curcumin was used as a drug modelnto study the loading/release behavior of LPE, finding that 50.08%nof curcumin could be encapsulated in LPE. The <i>in vitro</i> release of curcumin was pH-dependent. In addition, LPE exhibitednan outstanding protective effect against the ultraviolet-induced degradationnof curcumin.","PeriodicalId":521496,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147880153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}