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AntifoulingnManganese Oxide Nanoparticles: Synthesis,nCharacterization, and Applications for Enhanced MR Imaging of Tumors 防污纳米氧化锰：合成、表征及其在肿瘤增强磁共振成像中的应用
Figshare Pub Date : 2016-12-27 DOI: 10.1021/acsami.6b13844.s001
Peng Wang (34436), Jia Yang (427274), Benqing Zhou (1739368), Yong Hu (171926), Lingxi Xing (3603494), Fanli Xu (3603497), Mingwu Shen (550245), Guixiang Zhang (383795), Xiangyang Shi (550246)
{"title":"AntifoulingnManganese Oxide Nanoparticles: Synthesis,nCharacterization, and Applications for Enhanced MR Imaging of Tumors","authors":"Peng Wang (34436), Jia Yang (427274), Benqing Zhou (1739368), Yong Hu (171926), Lingxi Xing (3603494), Fanli Xu (3603497), Mingwu Shen (550245), Guixiang Zhang (383795), Xiangyang Shi (550246)","doi":"10.1021/acsami.6b13844.s001","DOIUrl":"https://doi.org/10.1021/acsami.6b13844.s001","url":null,"abstract":"Antifoulingnmanganese oxide (Mn<sub>3</sub>O<sub>4</sub>) nanoparticlesn(NPs) were synthesized by solvothermal decomposition of tris­(2,4-pentanedionato)nmanganese­(III) in the presence of trisodium citrate, followed by surfacenmodification with polyethylene glycol and l-cysteine. Thenas-prepared nanoparticles have a uniform size distribution, good colloidalnstability and good cytocompatibility. The modification of l-cysteine rendered the particles with much longer blood circulationntime (half-decay time of 28.4 h) than those without l-cysteinenmodification (18.5 h), and decreased macrophage cellular uptake. Thanksnto desirable antifouling property and relatively high r<sub>1</sub> relaxivity (3.66 mM<sup>–1</sup> s<sup>–1</sup>),nthe l-cysteine-modified Mn<sub>3</sub>O<sub>4</sub> NPs cannbe used for enhanced tumor magnetic resonance imaging applications.","PeriodicalId":521410,"journal":{"name":"Figshare","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147877273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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