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Increased Urinary Albumin Excretion But Less Damaged Renal Tubular Structures in Mice with Genetically Decreased Elmo1 Post Ischemia/Reperfusion Injury. 缺血/再灌注损伤后Elmo1基因降低小鼠尿白蛋白排泄增加，但肾小管结构受损较少。

Innovation discovery Pub Date : 2026-01-01 Epub Date: 2026-02-27 DOI: 10.53964/id.2026004

Meitong Chen, Qing Ma, Niroshani M W Wariyapperuma Appuhamillage, Yuye Wang, Yukako Kayashima, Nobuyo Maeda-Smithies, Feng Li

{"title":"Increased Urinary Albumin Excretion But Less Damaged Renal Tubular Structures in Mice with Genetically Decreased Elmo1 Post Ischemia/Reperfusion Injury.","authors":"Meitong Chen, Qing Ma, Niroshani M W Wariyapperuma Appuhamillage, Yuye Wang, Yukako Kayashima, Nobuyo Maeda-Smithies, Feng Li","doi":"10.53964/id.2026004","DOIUrl":"10.53964/id.2026004","url":null,"abstract":"Renal ischemia/reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), a potentially fatal syndrome characterized by a rapid decline in kidney function. The major cause of AKI is IRI. Our prior studies have demonstrated that genetically increased Elmo1 expression in mice aggravated several kidney pathologies including diabetic nephropathy and transition of AKI to chronic kidney disease induced by IRI. However, the effects of decreased expression of Elmo1 on IRI is unclear. We compared the kidney structures and functions between wild type (WT) mice and mice with genetically decreased Elmo1 expression (Elmo1 L/L ) 5 days after unilateral renal IR surgery. The WT-IRI mice had typical tubular injuries including necrosis and shedding of proximal tubular cells, but these morphological changes were less severe in Elmo1 L/L -IRI mice. In contrast, the urinary albumin excretion was elevated in Elmo1 L/L -IRI mice compared with WT counterparts. While the expression of inflammatory markers (e.g., Il6, Tnfa, Cxcl1 and Tlr4) was comparable between WT and Elmo1 L/L mice with IRI which significantly higher than control mice, the expression of antioxidant markers (e.g., Sod1 and Sod2) was preserved in Elmo1 L/L -IRI mice which was significantly decreased in WT-IRI mice. We conclude that Elmo1 L/L mice had preserved tubular structures but increased urinary albumin excretion after IRI, suggesting that the role of Elmo1 in IRI is complex and it merits future evaluation.","PeriodicalId":521311,"journal":{"name":"Innovation discovery","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12989112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Oxygen Evolution Reaction through In Situ Electrochemical Oxidation for the Structural Control of Co-Fe Prussian Blue Analogue 通过原位电化学氧化增强析氧反应以控制Co-Fe普鲁士蓝类似物的结构

Innovation discovery Pub Date : 2024-03-15 DOI: 10.53964/id.2024005

Yajuan Chen, Jing Tang, Weijun Li, Jielei Tu, Chao Huang

{"title":"Enhancing Oxygen Evolution Reaction through In Situ Electrochemical Oxidation for the Structural Control of Co-Fe Prussian Blue Analogue","authors":"Yajuan Chen, Jing Tang, Weijun Li, Jielei Tu, Chao Huang","doi":"10.53964/id.2024005","DOIUrl":"https://doi.org/10.53964/id.2024005","url":null,"abstract":"The development of exceptionally efficient catalysts for the oxygen evolution reaction (OER) and gaining a deep understanding of their activity is essential for advancing electrochemical conversion technologies. Prussian blue analogues (PBAs) serve as promising pre-catalysts for the OER. However, PBAs, typically prepared through the conventional co-precipitation method, exhibit a lower active site density and limited electrical transport, making them suitable precursors for the derivation of PBA derivatives. In this research, we identified a significant enhancement in the electrocatalytic performance of Co-Fe Prussian blue analogue (CoFe PBA) through electrochemical oxidation. The cubic CoFe PBA was synthesized by one-step co-precipitation method using adjusting the amount of sodium citrate and potassium ferricyanide. After the electrochemical treatment, CoFe PBA demonstrates remarkable attributes, including a low overpotential of 331mV at a current density of 10mA·cm-2, a small Tafel slope of 50.4mV·dec-1, and excellent long-term stability during electrolysis in a 1M KOH alkaline medium for over 37h. Moreover, the electrochemical oxidation of CoFe PBA was comprehensive, employing techniques such as Transmission electron microscope, Powder X-ray diffraction, and X-ray photoelectron spectroscopy. These analyses confirmed the presence of real active substances, including CoOOH and a part of FeOOH species, further supporting the observed improvements in electrocatalytic activity.","PeriodicalId":521311,"journal":{"name":"Innovation discovery","volume":"1 1","pages":"5-5"},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147884807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3