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Combating citrus greening disease by simultaneously targeting the pathogen and callose-mediated phloem occlusion 通过同时靶向病原菌和胼胝质介导的韧皮部闭塞来对抗柑橘绿化病
openRxiv Pub Date : 2026-01-03 DOI: 10.64898/2026.01.03.697484
Maryam Khalilzadeh, Chun-Yi Lin, John M. Chater, Amit Levy, Christopher Vincent
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引用次数: 0
Synthetic niches enable co-culture bioprocessing but are prone to mutational escape 合成生态位可以实现共培养生物处理，但容易发生突变逃逸
openRxiv Pub Date : 2025-11-25 DOI: 10.1101/2025.11.24.690348
Vincent Vandenbroucke, Juan Andrés Martínez, Lucas Henrion, Andrew Zicler, Samuel Telek, Laurie Josselin, Frank Delvigne
{"title":"Synthetic niches enable co-culture bioprocessing but are prone to mutational escape","authors":"Vincent Vandenbroucke, Juan Andrés Martínez, Lucas Henrion, Andrew Zicler, Samuel Telek, Laurie Josselin, Frank Delvigne","doi":"10.1101/2025.11.24.690348","DOIUrl":"https://doi.org/10.1101/2025.11.24.690348","url":null,"abstract":"","PeriodicalId":521296,"journal":{"name":"openRxiv","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147880832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mevalonate pathway activation in Ewing sarcoma reveals a 3D-specific synergy between statins and BCL-xL inhibition Ewing肉瘤的甲羟戊酸途径激活揭示了他汀类药物和BCL-xL抑制之间的3d特异性协同作用
openRxiv Pub Date : 2025-11-20 DOI: 10.1101/2025.11.20.689456
Branka Radic-Sarikas, Marica Markovic, Caterina Sturtzel, Mathias Ilg, Martha Magdalena Zylka, Didier Surdez, Martin Metzelder, Martin Distel, Aleksandr Ovsianikov, Florian Halbritter, Heinrich Kovar
{"title":"Mevalonate pathway activation in Ewing sarcoma reveals a 3D-specific synergy between statins and BCL-xL inhibition","authors":"Branka Radic-Sarikas, Marica Markovic, Caterina Sturtzel, Mathias Ilg, Martha Magdalena Zylka, Didier Surdez, Martin Metzelder, Martin Distel, Aleksandr Ovsianikov, Florian Halbritter, Heinrich Kovar","doi":"10.1101/2025.11.20.689456","DOIUrl":"https://doi.org/10.1101/2025.11.20.689456","url":null,"abstract":"","PeriodicalId":521296,"journal":{"name":"openRxiv","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147921130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
tugMedi: simulator of cancer-cell evolution for personalized medicine based on the genomic data of patients tugMedi：基于患者基因组数据的个性化医疗癌细胞进化模拟器
openRxiv Pub Date : 2025-07-03 DOI: 10.1101/2025.06.27.661855
Iurii Nagornov, Eisaku Furukawa, Momoko Nagai, Shigehiro Yagishita, Tatsuhiro Shibata, Mamoru Kato
{"title":"tugMedi: simulator of cancer-cell evolution for personalized medicine based on the genomic data of patients","authors":"Iurii Nagornov, Eisaku Furukawa, Momoko Nagai, Shigehiro Yagishita, Tatsuhiro Shibata, Mamoru Kato","doi":"10.1101/2025.06.27.661855","DOIUrl":"https://doi.org/10.1101/2025.06.27.661855","url":null,"abstract":"","PeriodicalId":521296,"journal":{"name":"openRxiv","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147911842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bringing the Genetically Minimal Cell to Life on a Computer in 4D 将基因最小的细胞带到4D计算机上
openRxiv Pub Date : 2025-06-15 DOI: 10.1101/2025.06.10.658899
Zane R. Thornburg, Andrew Maytin, Jiwoong Kwon, Troy A. Brier, Benjamin R. Gilbert, Enguang Fu, Yang-Le Gao, Jordan Quenneville, Tianyu Wu, Henry Li, Talia Long, Weria Pezeshkian, Lijie Sun, John I. Glass, Angad Mehta, Taekjip Ha, Zaida Luthey-Schulten
{"title":"Bringing the Genetically Minimal Cell to Life on a Computer in 4D","authors":"Zane R. Thornburg, Andrew Maytin, Jiwoong Kwon, Troy A. Brier, Benjamin R. Gilbert, Enguang Fu, Yang-Le Gao, Jordan Quenneville, Tianyu Wu, Henry Li, Talia Long, Weria Pezeshkian, Lijie Sun, John I. Glass, Angad Mehta, Taekjip Ha, Zaida Luthey-Schulten","doi":"10.1101/2025.06.10.658899","DOIUrl":"https://doi.org/10.1101/2025.06.10.658899","url":null,"abstract":"","PeriodicalId":521296,"journal":{"name":"openRxiv","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147903924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
D614G reshapes allosteric networks and opening mechanisms of SARS-CoV-2 spikes D614G重塑SARS-CoV-2尖峰的变构网络和开启机制
openRxiv Pub Date : 2025-03-11 DOI: 10.1101/2025.03.07.642081
Fiona L. Kearns, Anthony T. Bogetti, Carla Calvó-Tusell, Mac Kevin E. Braza, Lorenzo Casalino, Amanda J. Gramm, Sean Braet, Mia A. Rosenfeld, Harinda Rajapaksha, Bryan Barker, Ganesh Anand, Surl-Hee Ahn, Lillian T. Chong, Rommie E. Amaro
{"title":"D614G reshapes allosteric networks and opening mechanisms of SARS-CoV-2 spikes","authors":"Fiona L. Kearns, Anthony T. Bogetti, Carla Calvó-Tusell, Mac Kevin E. Braza, Lorenzo Casalino, Amanda J. Gramm, Sean Braet, Mia A. Rosenfeld, Harinda Rajapaksha, Bryan Barker, Ganesh Anand, Surl-Hee Ahn, Lillian T. Chong, Rommie E. Amaro","doi":"10.1101/2025.03.07.642081","DOIUrl":"https://doi.org/10.1101/2025.03.07.642081","url":null,"abstract":"","PeriodicalId":521296,"journal":{"name":"openRxiv","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of drug candidates against glioblastoma with machine learning and high-throughput screening of heterogeneous cellular models 利用机器学习和高通量筛选异质细胞模型鉴定抗胶质母细胞瘤候选药物
openRxiv Pub Date : 2025-03-07 DOI: 10.1101/2025.03.06.641926
Vanessa Smer-Barreto, Richard J. R. Elliott, John C. Dawson, Álvaro Lorente-Macías, Asier Unciti-Broceta, Diego A. Oyarzún, Neil O. Carragher
{"title":"Identification of drug candidates against glioblastoma with machine learning and high-throughput screening of heterogeneous cellular models","authors":"Vanessa Smer-Barreto, Richard J. R. Elliott, John C. Dawson, Álvaro Lorente-Macías, Asier Unciti-Broceta, Diego A. Oyarzún, Neil O. Carragher","doi":"10.1101/2025.03.06.641926","DOIUrl":"https://doi.org/10.1101/2025.03.06.641926","url":null,"abstract":"","PeriodicalId":521296,"journal":{"name":"openRxiv","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147908256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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