iMetaMed最新文献

筛选

英文中文

Oat β‐Glucan and Galactooligosaccharides Influence Gallstone Formation by Modulating the Gut Microbiota, Particularly Desulfovibrionales 燕麦β -葡聚糖和半乳糖低聚糖通过调节肠道微生物群，特别是Desulfovibrionales影响胆结石的形成

iMetaMed Pub Date : 2026-02-01 DOI: 10.1002/imm3.70029

Liang Tian, Yanyan Lin, Ping Yue, Long Gao, Leiqing Wang, Chongfei Huang, Jinyu Zhao, Ningzu Jiang, Jiahui xi, Haidong Ma, Zhen Liu, Ruyang Zhong, Wenkang Fu, Ningning Mi, Mingzhen Bai, Bodong Zhang, Lunzhi Dai, Jiang Li, Hu Chen, Jinqiu Yuan, Wenbo Meng

{"title":"Oat β‐Glucan and Galactooligosaccharides Influence Gallstone Formation by Modulating the Gut Microbiota, Particularly Desulfovibrionales","authors":"Liang Tian, Yanyan Lin, Ping Yue, Long Gao, Leiqing Wang, Chongfei Huang, Jinyu Zhao, Ningzu Jiang, Jiahui xi, Haidong Ma, Zhen Liu, Ruyang Zhong, Wenkang Fu, Ningning Mi, Mingzhen Bai, Bodong Zhang, Lunzhi Dai, Jiang Li, Hu Chen, Jinqiu Yuan, Wenbo Meng","doi":"10.1002/imm3.70029","DOIUrl":"https://doi.org/10.1002/imm3.70029","url":null,"abstract":"ABSTRACT Cholesterol gallstone disease is a prevalent ailment of the digestive system, accumulating evidence indicates a significant association between gut flora and gallstone formation. In the present research, we found that oat β‐glucan promotes gallstone formation, whereas galactooligosaccharides exerted inhibitory effects. Notably, these opposing effects were neutralized upon co‐administration of both prebiotics. Further research demonstrated that both prebiotics act primarily through modulating the abundance of Desulfovibrionales. The metabolic product of Desulfovibrionales, H 2 S, can directly activate the hepatic farnesoid X receptor (FXR) and thereby suppress bile acid production via FXR‐SHP signaling. Additionally, H 2 S can increase secondary bile acid levels (DCA, LCA) by promoting intestinal 7α‐dehydroxylase function. These secondary bile acids further decrease bile acid production in the liver via the intestinal FXR‐FGF15 cascade. Moreover, the upregulated production of secondary bile acids also enhances bile hydrophobicity. Collectively, these effects induce biliary cholesterol overloading, and ultimately promote gallstone formation. Our findings elucidate the effect of oat β‐glucan and galactooligosaccharides on gallstone formation, and suggest that alterations in Desulfovibrionales abundance and its influence on hepatic FXR‐SHP and intestinal FXR‐FGF15 pathways may underlie the potential mechanisms.","PeriodicalId":521295,"journal":{"name":"iMetaMed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/imm3.70029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isorhamnetin Alleviates Renal Fibrosis Induced by Renal Tubular Epithelial Cell Senescence Via Inhibition of the IL‐6/IL‐6R Signaling Pathway 异鼠李素通过抑制IL - 6/IL - 6R信号通路减轻肾小管上皮细胞衰老诱导的肾纤维化

iMetaMed Pub Date : 2026-01-17 DOI: 10.1002/imm3.70028

Weifei Liang, Xiangqiu Chen, Tao Wu, Xichun Zheng, Shaohua Zeng, Qingchun Zhou, Wen Ma, Hao Lin, Donglin Sun

{"title":"Isorhamnetin Alleviates Renal Fibrosis Induced by Renal Tubular Epithelial Cell Senescence Via Inhibition of the IL‐6/IL‐6R Signaling Pathway","authors":"Weifei Liang, Xiangqiu Chen, Tao Wu, Xichun Zheng, Shaohua Zeng, Qingchun Zhou, Wen Ma, Hao Lin, Donglin Sun","doi":"10.1002/imm3.70028","DOIUrl":"https://doi.org/10.1002/imm3.70028","url":null,"abstract":"ABSTRACT Chronic kidney disease (CKD) is a major global health issue. Kidney fibrosis is a key mechanism leading to end‐stage renal disease. Senescence of renal tubular epithelial cells (RTECs) and the senescence‐associated secretory phenotype (SASP) factors they release are crucial in kidney fibrosis progression. While isorhamnetin, the active component of Astragalus membranaceus , has demonstrated promise in combating senescence/aging and fibrosis, its precise mechanism of action remains poorly understood. This study aims to elucidate the mechanisms through which isorhamnetin mitigates RTEC senescence and kidney fibrosis, specifically by modulating the interleukin‐6 (IL‐6) signaling pathway. The findings indicate that isorhamnetin significantly attenuates kidney fibrosis in aging mice, inhibiting IL‐6 secretion from senescent RTECs and reducing its accumulation in kidney tissues. In vitro analyses further revealed that isorhamnetin disrupted IL‐6 signaling by competitively binding to the IL‐6 receptor, thereby slowing RTEC senescence. Additional investigations demonstrated that isorhamnetin's inhibition of IL‐6 secretion from senescent RTECs impacted macrophage M2 polarization and the transformation of fibroblasts into myofibroblasts, thus decelerating the progression of kidney fibrosis. This study highlights the critical role of isorhamnetin in alleviating RTEC senescence and kidney fibrosis through the suppression of the IL‐6 signaling pathway, underscoring its potential for clinical application in CKD treatment.","PeriodicalId":521295,"journal":{"name":"iMetaMed","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/imm3.70028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potassium Sorbate Triggers Kidney Injury via Dysregulated Intercellular Communication: A Study Combining Network Toxicology, Machine Learning, Molecular Docking, and Single‐Cell RNA Sequencing 山梨酸钾通过细胞间通讯失调引发肾损伤：一项结合网络毒理学、机器学习、分子对接和单细胞RNA测序的研究

iMetaMed Pub Date : 2025-11-23 DOI: 10.1002/imm3.70017

Yangmin Wu, Liang Yu, Jintao Liang, Gökhan Zengin, Qian Zhang, Mengyao Li

{"title":"Potassium Sorbate Triggers Kidney Injury via Dysregulated Intercellular Communication: A Study Combining Network Toxicology, Machine Learning, Molecular Docking, and Single‐Cell RNA Sequencing","authors":"Yangmin Wu, Liang Yu, Jintao Liang, Gökhan Zengin, Qian Zhang, Mengyao Li","doi":"10.1002/imm3.70017","DOIUrl":"https://doi.org/10.1002/imm3.70017","url":null,"abstract":"ABSTRACT Acute kidney injury (AKI) is a clinically significant syndrome, characterized by high mortality rates and the potential for progression to chronic kidney disease. Potassium sorbate (PS), a widely‐used food preservative with a high safety profile, has been identified as a potential risk factor for inducing acute kidney injury. However, the mechanism of its potential nephrotoxicity, particularly in relation to the onset of AKI, remains unclear. This study provides a comprehensive examination of the molecular mechanisms of PS‐induced kidney injury, employing a variety of methodologies including network toxicology, molecular docking, molecular dynamics simulation, machine learning, and single‐cell analysis. The findings suggest that PS interacts with key targets such as matrix metallopeptidase 9 (MMP9) and amyloid precursor protein (APP), affecting lipid metabolism and atherosclerosis, as well as AGE‐RAGE signaling pathways. These interactions trigger oxidative stress, inflammatory responses, and metabolic disorders, thereby facilitating the development of acute kidney injury. Machine learning screening identified the APP as a key regulatory gene. Furthermore, single‐cell analysis revealed that APP, via APP‐CD74 and APP‐PTGER2 ligand–receptor pairs, mediates interactions between endothelial cells and immune cells. This provides novel cellular evidence for understanding PS‐induced kidney tubular inflammation and microenvironmental imbalance. This study not only offers systematic scientific evidence for evaluating the nephrotoxicity of PS, but also introduces an innovative research paradigm that integrates multiple dimensions for the safety assessment of food additives and the exploration of the molecular mechanisms of acute kidney injury.","PeriodicalId":521295,"journal":{"name":"iMetaMed","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/imm3.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4