Microplastics (Basel, Switzerland)最新文献

Micro- and Nanoplastics and Pulmonary Health: The Current State of Research. 微、纳米塑料与肺部健康：研究现状。

Microplastics (Basel, Switzerland) Pub Date : 2026-02-09 DOI: 10.3390/microplastics5010029

Charles E Bardawil, Jarrett Dobbins, Shannon Lankford, Adam C Soloff, Rajeev Dhupar

{"title":"Micro- and Nanoplastics and Pulmonary Health: The Current State of Research.","authors":"Charles E Bardawil, Jarrett Dobbins, Shannon Lankford, Adam C Soloff, Rajeev Dhupar","doi":"10.3390/microplastics5010029","DOIUrl":"10.3390/microplastics5010029","url":null,"abstract":"Micro- and nanoplastics are human made environmental contaminants that pose a growing concern for our health, particularly through airborne exposures. Although human autopsy studies confirm that micro- and nanoplastics are retained in lung tissue, our understanding of their short- and long-term effects on the pulmonary system is limited. We reviewed the existing literature to evaluate the effects of micro- and nanoplastics on the respiratory system and how their downstream effects may induce respiratory disease. In vivo and in vitro studies demonstrate that micro- and nanoplastics appear to have the capacity to disrupt pulmonary homeostasis through oxidative stress, immune activation, epithelial remodeling, and surfactant interference. Unfortunately, most available micro- and nanoplastics exposure studies are conducted using environmentally irrelevant plastics at high doses, which limits the accuracy and validity of conclusions regarding biological mechanisms that may contribute to chronic lung disease. To close this gap, future studies must adopt standardized, human-relevant models and realistic exposure scenarios. This includes using advanced in vitro and ex vivo platforms, and environmentally representative micro- and nanoplastics (rather than polystyrene spheres) to improve clinical relevance and support effective prevention and risk mitigation strategies.","PeriodicalId":521247,"journal":{"name":"Microplastics (Basel, Switzerland)","volume":"5 1","pages":"29"},"PeriodicalIF":0.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12981156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microplastic-Mediated Delivery of Di-butyl Phthalate Alters C. elegans Lifespan and Reproductive Fidelity. 微塑料介导的邻苯二甲酸二丁酯递送改变秀丽隐杆线虫的寿命和繁殖保真度。

Microplastics (Basel, Switzerland) Pub Date : 2025-12-01 DOI: 10.3390/microplastics4040096

Chiara Angelyn O Maldonado, David M Mares, Paola C Garcia, Maria F Gamez, Midori R Flores, Alyssa D Friudenberg, Ryan L Peterson, Jennifer C Harr

{"title":"Microplastic-Mediated Delivery of Di-butyl Phthalate Alters C. elegans Lifespan and Reproductive Fidelity.","authors":"Chiara Angelyn O Maldonado, David M Mares, Paola C Garcia, Maria F Gamez, Midori R Flores, Alyssa D Friudenberg, Ryan L Peterson, Jennifer C Harr","doi":"10.3390/microplastics4040096","DOIUrl":"10.3390/microplastics4040096","url":null,"abstract":"Microplastics harbor chemical additives and absorb pollutants from the environment. Microplastics pose a human health threat and have been found in nearly all human tissues. The toxicological pathways and physiological effects of microplastic-mediated chemical exposure following ingestion remain unknown. Here we use Caenorhabditis elegans to investigate the effects of di-butyl phthalate and polystyrene microplastic mixtures on fertility and lifespan. Our studies demonstrate that 1 μm microplastics at 1 mg/L exposure levels result in decreased brood size, whereas 1000 times fewer microplastics (1 μg/L) did not affect the number of eggs laid. While there was no change in brood size at 1 μg/L microplastic exposure levels, there was an increase in embryonic lethality. Microplastics-mediated delivery of di-butyl phthalate to C. elegans significantly reduced brood size and increased embryonic lethality compared to exposure to microplastics alone. This reproductive toxicity is potentially due to a stress response via DAF-16, as observed with microplastics and di-butyl phthalate co-exposure. Furthermore, chronic exposure (from hatching onward) to microplastics shortened the lifespan of C. elegans, which was further reduced with di-butyl phthalate co-exposure. The exacerbated defects observed with co-exposure to phthalate-containing microplastics underscore the risks associated with microplastics releasing the additives and/or chemicals that they have absorbed from the environment.","PeriodicalId":521247,"journal":{"name":"Microplastics (Basel, Switzerland)","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12889887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146169280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Making Fluorescent Nylon, Polypropylene, and Polystyrene Microplastics for In Vivo and In Vitro Imaging. 荧光尼龙，聚丙烯和聚苯乙烯微塑料体内和体外成像。

Microplastics (Basel, Switzerland) Pub Date : 2025-11-04 DOI: 10.3390/microplastics4040084

Charles E Bardawil, Jarrett Dobbins, Shannon Lankford, Saif Chowdrey, Jack Shumway, Gayathriy Balamayooran, Cedric Schaack, Rajeev Dhupar

{"title":"Making Fluorescent Nylon, Polypropylene, and Polystyrene Microplastics for In Vivo and In Vitro Imaging.","authors":"Charles E Bardawil, Jarrett Dobbins, Shannon Lankford, Saif Chowdrey, Jack Shumway, Gayathriy Balamayooran, Cedric Schaack, Rajeev Dhupar","doi":"10.3390/microplastics4040084","DOIUrl":"10.3390/microplastics4040084","url":null,"abstract":"Microplastics (MPs) are synthetic environmental pollutants increasingly linked to adverse human health effects. To study their biological impact, researchers require access to environmentally relevant MPs that can be accurately tracked in biological systems. However, most ambient MPs are composed of non-conjugated polymers that lack intrinsic fluorescence, limiting their utility in live-cell or in vivo imaging. Addressing this challenge, we present two alternative labeling approaches that enable visualization, tracking, and quantification of MPs. First, we stained nylon and polypropylene MPs with Rhodamine 6G, a fluorescent dye known for its stability and compatibility with in vivo applications. These labeled MPs retained strong fluorescence in murine lung tissue for up to one week, as confirmed by fluorescent microscopy. Second, we conjugated aminated polystyrene microspheres with IRDye-800CW, a near-infrared fluorophore that enables high-resolution imaging with minimal tissue autofluorescence via an In Vivo Imaging System and confocal microscopy. In vivo experiments revealed organ-specific accumulation of IRDye-labeled MPs, with a 2.8-fold increase in the liver and a 5-fold increase in spleen compared to controls, detectable up to 72 h post-injection. These labeling strategies provide researchers with practical tools to visualize and study the biodistribution of MPs in biological systems, advancing efforts to understand their health implications.","PeriodicalId":521247,"journal":{"name":"Microplastics (Basel, Switzerland)","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13245631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148214221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Exposures to Micro- and Nanoplastics in Water and Data Needed to Understand Potential Health Effects-A-State of the Science Review. 人类暴露于水中的微塑料和纳米塑料以及了解潜在健康影响所需的数据-科学评论的现状。

Microplastics (Basel, Switzerland) Pub Date : 2025-09-05 DOI: 10.3390/microplastics4030060

Max Zarate-Bermudez, Gaston Casillas, Janie Hils, Michael Yeh, Yulia Carroll

{"title":"Human Exposures to Micro- and Nanoplastics in Water and Data Needed to Understand Potential Health Effects-A-State of the Science Review.","authors":"Max Zarate-Bermudez, Gaston Casillas, Janie Hils, Michael Yeh, Yulia Carroll","doi":"10.3390/microplastics4030060","DOIUrl":"10.3390/microplastics4030060","url":null,"abstract":"Human exposure to micro- and nanoplastics (MNPs) in the environment and their potential health effects are of growing public interest. Regarding water, that interest grows because multiple studies found MNPs in different matrices including tap and bottled water. We intended to (i) understand how MNPs enter freshwater systems and drinkable water, (ii) assess the evidence of human exposure to MNPs in water, and (iii) identify data gaps to support the determination of potential health effects. We searched the literature and selected studies via rigorous inclusion criteria, analyzed the data assessing the reliability of findings, and identified data gaps associated with human exposure to MNPs in water. The lack of standard sampling and analytical methods for testing MNPs in water constitutes a barrier to make accurate comparisons. The diverse analytical methods to fully characterize MNPs led to different findings in samples of similar matrices. Current drinking and wastewater treatment systems are not designed to remove MNPs. However, efforts to enhance the precision and accuracy of MNPs' characterization and their removal by treatment systems are promising. Therefore, addressing data gaps could produce reliable data for conducting exposure and risk assessments, protect our communities, and control the mobility of MNPs to minimize exposures.","PeriodicalId":521247,"journal":{"name":"Microplastics (Basel, Switzerland)","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13055644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147641236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0