Discover biotechnologyPub Date : 2025-01-01Epub Date: 2025-11-27DOI: 10.1007/s44340-025-00043-w
Liszt Y C Madruga, Somayeh Baghersad, Paulo C F Câmara, Roberta M Sabino, Matt J Kipper, Ketul C Popat
{"title":"Carboxymethyl kappa carrageenan polyelectrolyte multilayers as blood contacting surfaces.","authors":"Liszt Y C Madruga, Somayeh Baghersad, Paulo C F Câmara, Roberta M Sabino, Matt J Kipper, Ketul C Popat","doi":"10.1007/s44340-025-00043-w","DOIUrl":"10.1007/s44340-025-00043-w","url":null,"abstract":"<p><p>This research introduces carboxymethyl kappa-carrageenan-chitosan polyelectrolyte multilayers as a promising and sustainable alternative to heparin, used in surface treatments for blood-contacting medical devices. The polysaccharide-based surface coatings have good cytocompatibility and resist microbial adhesion of both Pseudomonas aeruginosa and Staphylococcus aureus. The blood compatibility of surfaces containing carboxymethyl-kappa-carrageenan was directly compared to similar polyelectrolyte multilayers containing heparin. The carboxymethyl-kappa-carrageenan surfaces inhibit whole-blood clotting like heparin-containing surfaces. Blood clotting is mediated by both protein-surface and cell-surface interactions. The carboxymethyl-kappa-carrageenan surfaces adsorb more fibrinogen and less albumin than the heparin surfaces, and they also exhibit reduced platelet and leukocyte adhesion, compared to heparin surfaces. These results suggest that carboxymethyl-kappa-carrageenan may represent a sustainable alternative to heparin as an anticoagulant surface modification.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s44340-025-00043-w.</p>","PeriodicalId":521137,"journal":{"name":"Discover biotechnology","volume":"2 1","pages":"37"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12671015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145673501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}