Academia molecular biology and genomics最新文献

筛选

英文中文

Rapid assessment of clinical severity for salmonellosis cases via protein family domain analysis and machine learning. 通过蛋白质家族结构域分析和机器学习快速评估沙门氏菌病病例的临床严重程度。

Academia molecular biology and genomics Pub Date : 2025-01-01 Epub Date: 2025-06-30 DOI: 10.20935/acadmolbiogen7776

Aakash Bhattacharyya, Sudip Panday, David Ussery

{"title":"Rapid assessment of clinical severity for salmonellosis cases via protein family domain analysis and machine learning.","authors":"Aakash Bhattacharyya, Sudip Panday, David Ussery","doi":"10.20935/acadmolbiogen7776","DOIUrl":"10.20935/acadmolbiogen7776","url":null,"abstract":"Salmonella is a common pathogen, infecting more than a million people yearly. Rapid assessment of clinical case severity is essential for improving patient outcomes and optimizing healthcare resources. Advancements in genome sequencing technologies have enabled the analysis of bacterial genomes from many clinical cases, opening up new opportunities for precise and timely diagnosis. This study proposes a genome-based framework for identifying critical Salmonella cases before the onset of critical symptoms and facilitating early medical intervention. By leveraging protein family (Pfam) domains as the representation for genomic data, the complex genetic profiles of Salmonella cases are simplified into interpretable features. The severity levels of cases were investigated through rigorous data analysis, resulting in a set of 70 Pfam domains that could be potentially used as biomarkers. Machine Learning was employed to assess the predictive power of the curated Pfam biomarkers, achieving high accuracy (~93%) in sorting cases into critical, moderate, and mild categories. The results demonstrate the efficacy of the proposed approach. This framework highlights the potential of using bacterial genomic data in clinical decision-making, opening the window for timely personalized interventions for Salmonella infection management.","PeriodicalId":521050,"journal":{"name":"Academia molecular biology and genomics","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0