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Lifelong high-fat, high-sucrose diet causes sex-specific heart dysfunction in mouse offspring. 终生高脂肪、高糖饮食会导致小鼠后代的性别特异性心脏功能障碍。

Academia medicine Pub Date : 2025-01-01 Epub Date: 2025-07-24 DOI: 10.20935/acadmed7821

Yun-Ju Fang, Filip Konecny, Eunhee Chung

{"title":"Lifelong high-fat, high-sucrose diet causes sex-specific heart dysfunction in mouse offspring.","authors":"Yun-Ju Fang, Filip Konecny, Eunhee Chung","doi":"10.20935/acadmed7821","DOIUrl":"10.20935/acadmed7821","url":null,"abstract":"Maternal obesity and high-fat, high-sucrose (HFHS) diets during development increase cardiometabolic risk in offspring, but long-term, sex-specific cardiac effects remain underexplored. This study examined how continuous HFHS exposure impacts cardiac function in male and female mice. Female dams were fed a control standard chow (CON) diet or HFHS diet for 8 weeks before pregnancy, continuing through gestation and lactation. Offspring were maintained on their dam's diet until 29-32 weeks of age. Body composition and cardiac function were assessed using pressure-volume (P-V) loop analysis. HFHS offspring exhibited increased body weight and fat mass, with males showing greater adiposity. Lean mass was higher in males, but relative lean mass decreased in both sexes by 22 weeks in response to the HFHS diet. Cardiac assessments revealed load-dependent and load-independent impairments. HFHS exposure increased end-diastolic and end-systolic volumes, reduced ejection fraction, and lowered end-systolic elastance, indicating systolic dysfunction in both sexes. Diastolic function showed sex-specific alterations; HFHS exposure in males led to slower myocardial relaxation (less negative dP/dt min), while in females it increased end-diastolic elastance (Eed), suggesting greater ventricular stiffness. Ventricular-arterial coupling (Ees/Ea) was reduced in HFHS-exposed animals of both sexes, with females showing more pronounced impairments. Our results highlight sex-specific cardiac dysfunction in HFHS-exposed offspring, with females more susceptible to myocardial stiffness and coupling deficits. This underscores the need for sex-tailored interventions to mitigate long-term cardiovascular risks from early-life HFHS exposure.","PeriodicalId":520950,"journal":{"name":"Academia medicine","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12341393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory bowel disease patients believe cannabis and cannabidiol oil relieve symptoms. 炎症性肠病患者认为大麻和大麻二酚油可以缓解症状。

Academia medicine Pub Date : 2025-01-01 Epub Date: 2025-06-17 DOI: 10.20935/acadmed7773

Ayati Lala, Alexander Rodriguez-Palacios, Fabio Cominelli, Abigail Raffner Basson

{"title":"Inflammatory bowel disease patients believe cannabis and cannabidiol oil relieve symptoms.","authors":"Ayati Lala, Alexander Rodriguez-Palacios, Fabio Cominelli, Abigail Raffner Basson","doi":"10.20935/acadmed7773","DOIUrl":"10.20935/acadmed7773","url":null,"abstract":"Background: Patients with Inflammatory bowel disease (IBD) often seek alternative therapies for symptom management. This study investigates the perceptions, consumption patterns, and reported outcomes of cannabis and cannabidiol (CBD) oil use among IBD patients and controls.Methods: A 37-question survey was administered to 139 participants (IBD patients, n = 93; control/non-IBD participants, n = 33) to assess usage frequency and beliefs regarding cannabis and CBD oil as treatment for IBD. The survey also evaluated the impact of these substances on IBD symptoms, quality of life, and opioid use.Results: Cannabis consumption was higher in IBD patients (57, 53.8%) than controls (15, 45.5%) with both groups strongly supporting medical cannabis use (IBD; 92, 86.8% vs. controls; 29, 84.9%). Most IBD patients believed cannabis (67, 63.2%), CBD oil (60, 56.6%), corticosteroids (77, 73.3%), and biologics/immunosuppressants (85, 81.0%) had a somewhat-extremely beneficial effect in relieving IBD symptoms. Over 50% of IBD cannabis users reported relief from abdominal pain, other pain, stress, anxiety, depression, and nausea/vomiting, with Crohn's disease patients experiencing significantly more relief than ulcerative colitis patients for certain symptoms (p < 0.05). Notably, 19.4% of IBD patients reported decreased opioid use, and 14.5% reported induced remission with cannabis or CBD oil.Conclusions: Consumption of cannabis and CBD oil was perceived as beneficial for relieving IBD, with many reporting significant symptom relief from using these substances. The strong support of cannabis and CBD oil as medical treatments and therapeutic effects highlights the potential for cannabis and CBD oil as treatments in IBD.","PeriodicalId":520950,"journal":{"name":"Academia medicine","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0