Polymer science & technology (Washington, D.C.)最新文献

Enhanced Hydrophilicity and Antifouling Performance of PEG with Sulfoxide-Containing Side Chains for Nanomedicine Applications. 含亚砜侧链聚乙二醇在纳米医学中的亲水性和防污性能。

Polymer science & technology (Washington, D.C.) Pub Date : 2025-08-15 eCollection Date: 2025-09-23 DOI: 10.1021/polymscitech.5c00084

Yuhao Zhang, Mingdi Hu, Ruijing Xin, Xin Xu, Ze Zhang, Hui Peng, Rong Cai, Chunying Chen, Andrew K Whittaker, Changkui Fu

{"title":"Enhanced Hydrophilicity and Antifouling Performance of PEG with Sulfoxide-Containing Side Chains for Nanomedicine Applications.","authors":"Yuhao Zhang, Mingdi Hu, Ruijing Xin, Xin Xu, Ze Zhang, Hui Peng, Rong Cai, Chunying Chen, Andrew K Whittaker, Changkui Fu","doi":"10.1021/polymscitech.5c00084","DOIUrl":"10.1021/polymscitech.5c00084","url":null,"abstract":"Poly-(ethylene) glycol (PEG) has been widely used as an antifouling coating material for nanomedicines to improve their stability and safety. However, a growing number of studies have indicated that PEG is immunogenic and can cause unwanted immune responses, highlighting the need to develop alternative antifouling polymers for applications in nanomedicine. In this study, we report an innovative polymer, poly-(2-(methylsulfinyl)-ethyl glycidyl ether) (PMSOEGE), composed of a PEG backbone structure with sulfoxide-containing side chains. We demonstrated that PMSOEGE is highly biocompatible and more hydrophilic than conventional PEG due to the presence of highly polar and hydrophilic sulfoxide structures. Furthermore, PMSOEGE exhibits a much lower association with anti-PEG antibodies, as confirmed by an in vitro competitive enzyme-linked immunosorbent assay (ELISA). We applied PMSOEGE as a coating material for iron oxide nanoparticles (IONPs) and demonstrated that the PMSOEGE-coated IONPs showed significantly lower cellular uptake by macrophages compared with PEGylated IONPs. Protein corona analysis indicated that fewer proteins were associated with IONP@PMSOEGE. The results highlight the superior antifouling properties of PMSOEGE and highlight its potential to serve as a PEG alternative for various biological applications.","PeriodicalId":520914,"journal":{"name":"Polymer science & technology (Washington, D.C.)","volume":"1 7","pages":"640-650"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodegradable, Biocompatible, and Crosslinkable Polymers Enable Biosafe and Sustainable Soft Gels and Nanogels for Biomedical Applications. 可生物降解，生物相容性和交联聚合物使生物安全和可持续的软凝胶和纳米凝胶用于生物医学应用。

Polymer science & technology (Washington, D.C.) Pub Date : 2025-06-13 eCollection Date: 2025-08-26 DOI: 10.1021/polymscitech.5c00049

Binglin Sui, Safiya Nisar, Amrit Regmi, Elisabeth Starosta

{"title":"Biodegradable, Biocompatible, and Crosslinkable Polymers Enable Biosafe and Sustainable Soft Gels and Nanogels for Biomedical Applications.","authors":"Binglin Sui, Safiya Nisar, Amrit Regmi, Elisabeth Starosta","doi":"10.1021/polymscitech.5c00049","DOIUrl":"10.1021/polymscitech.5c00049","url":null,"abstract":"To date, more biodegradable polymers have been developed due to the growing recognition of the advantages of biodegradable and biocompatible polymers for biomedical applications. In this study, we introduce the synthesis and characterization of innovative polymers that incorporate biodegradable backbones composed of trimethylolpropane and adipic acid moieties and biocleavable side chains containing pyridyl disulfide groups. Notably, their synthesis is straightforward and catalyst-free under ambient conditions, minimizing potential toxicity and immune responses caused by catalyst residues in polymer materials. The new polymers have desired molecular weight (Mn: 18.8 kDa) with a narrow dispersion (PDI: 1.32) and offer complete biodegradability, biocompatibility, crosslinking capabilities, and opportunities for covalent chemical modifications. These features make them particularly suitable for use in biomedical materials and devices. Additionally, due to their unique properties, these polymers have been successfully formulated into polymeric gels and nanogels, which are biodegradable as well. Using a near-infrared fluorescent probe as a model cargo, we demonstrated the creation of a biosafe and sustainable nanogel system for agent delivery, with an average size of approximately 70 nm. In these nanogels, agent molecules are covalently attached to the scaffold, thereby avoiding uncontrolled premature release and burst release in the bloodstream and mitigating associated systemic toxicity and side effects. The nanogels can also be easily functionalized with targeting ligands for disease-specific delivery. These polymers induced minimal toxicity toward human cells and displayed excellent in vivo biocompatibility, highlighting the significant potential of their polymeric gels and nanogels for a broad spectrum of biomedical applications.","PeriodicalId":520914,"journal":{"name":"Polymer science & technology (Washington, D.C.)","volume":"1 6","pages":"569-579"},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144987162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ionic Crosslinking Improves the Stiffness and Toughness of Protein Hydrogels. 离子交联提高了蛋白质水凝胶的硬度和韧性。

Polymer science & technology (Washington, D.C.) Pub Date : 2025-05-19 eCollection Date: 2025-06-24 DOI: 10.1021/polymscitech.5c00024

Linglan Fu, Hongbin Li

{"title":"Ionic Crosslinking Improves the Stiffness and Toughness of Protein Hydrogels.","authors":"Linglan Fu, Hongbin Li","doi":"10.1021/polymscitech.5c00024","DOIUrl":"10.1021/polymscitech.5c00024","url":null,"abstract":"Protein-based hydrogels are promising materials for biomedical and materials science applications. However, engineering hydrogels with both high stiffness and high toughness, a key requirement for many applications, remains challenging. Recently, by using the denatured crosslinking method, we developed highly stiff and tough protein hydrogels based on the polyprotein (FL)8 via introducing chain entanglements into the hydrogel network, which allow for stiffening the hydrogel without sacrificing toughness. These hydrogels exhibited a Young's modulus of ∼0.7 MPa and breaking strain of ∼100% in tensile tests. To further enhance their stretchability and toughness, here we report the engineering of a protein/alginate hybrid hydrogel, in which the protein and alginate networks are covalently joined. Alginate was chemically modified with tyramine to introduce phenol groups, allowing the modified alginate to be photochemically crosslinked together with the polyprotein (FL)8 to form a hybrid network hydrogel. Using calcium-mediated ionic crosslinking, we demonstrated the feasibility to tune the Young's modulus and breaking strain of these hydrogels by controlling the degree of tyramine modification of alginate. Our results showed that incorporating noncovalent ionic crosslinking into the hydrogel network increased the hydrogel's stretchability from ∼100% to over 200% without compromising stiffness, significantly improving the hydrogel's toughness. This work expands the mechanical tunability of protein hydrogels and the repertoire of strategies for engineering hydrogels with a broad range of mechanical properties.","PeriodicalId":520914,"journal":{"name":"Polymer science & technology (Washington, D.C.)","volume":"1 4","pages":"342-350"},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graphitic Carbon Nitride Embedded Bio-Based Acrylic Films as Surface Active Photocatalysts. 石墨氮化碳包埋生物基丙烯酸薄膜作为表面活性光催化剂。

Polymer science & technology (Washington, D.C.) Pub Date : 2024-12-19 eCollection Date: 2025-03-25 DOI: 10.1021/polymscitech.4c00017

Chuyue Lu, Niklas Lorenz, Hanieh Bazyar, Giulio Malucelli, Baris Kumru

{"title":"Graphitic Carbon Nitride Embedded Bio-Based Acrylic Films as Surface Active Photocatalysts.","authors":"Chuyue Lu, Niklas Lorenz, Hanieh Bazyar, Giulio Malucelli, Baris Kumru","doi":"10.1021/polymscitech.4c00017","DOIUrl":"10.1021/polymscitech.4c00017","url":null,"abstract":"Soybean oil, a sustainable and renewable resource, has gained increasing industrial relevance through its derivatives, such as acrylated soybean oil, which is now produced at significant commercial scales. In contrast, graphitic carbon nitride (g-CN), a metal-free polymeric semiconductor, remains unexplored in industrial polymer systems. This study explores the integration of graphitic carbon nitride into bio-based acrylic resins using a rapid UV-curing process at a belt speed of 1 m/min. The resulting nanocomposite films, incorporating 10% nanoparticle loading and with an average thickness of 200 μm, demonstrate promising photocatalytic properties with a bandgap of 2.7 eV. The photocatalytic performance of these films is thoroughly evaluated via dye degradation experiments, revealing enhanced surface-driven activity, particularly in alcohol-based media. While the hydrophobic nature of the films limits dye removal in aqueous environments (25% removal efficiency in 5 h), complete photodegradation of methylene blue is achieved in alcohol within 5 h. Moreover, the films maintain their photocatalytic efficiency over five cycles with no significant performance deprivation.","PeriodicalId":520914,"journal":{"name":"Polymer science & technology (Washington, D.C.)","volume":"1 1","pages":"46-52"},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Side-Chain Molecular Features on Aqueous Coacervation of Multifunctional Homopolypeptides. 侧链分子特征对多功能均多肽水溶液凝聚的影响。

Polymer science & technology (Washington, D.C.) Pub Date : 2024-10-23 eCollection Date: 2025-03-25 DOI: 10.1021/polymscitech.4c00003

Wendell A Scott, Isaac Benavides, Timothy J Deming

{"title":"Influence of Side-Chain Molecular Features on Aqueous Coacervation of Multifunctional Homopolypeptides.","authors":"Wendell A Scott, Isaac Benavides, Timothy J Deming","doi":"10.1021/polymscitech.4c00003","DOIUrl":"10.1021/polymscitech.4c00003","url":null,"abstract":"Three different series of amino acid side-chain functionalized homopolypeptides were prepared as variants of previously reported α-helical, coacervate-forming cationic polypeptides. Studies of the physical behavior of these polypeptides in aqueous media in the presence of multivalent counterions enabled a better understanding of the molecular requirements for coacervate formation of side-chain functionalized homopolypeptides. Variation in lengths of side-chain amino acid or linker segments in cationic α-helical polypeptides was found either to prohibit coacervate formation or to allow adjustment of the phase transition temperature. A series of charge-reversed, anionic amino acid side-chain functionalized homopolypeptides were also prepared and found to be α-helical and able to form coacervates similar to analogous cationic homopolypeptides. These results illustrate the ability to predictably tune coacervation properties via molecular adjustment of side-chains in homopolypeptides and show that amino acid side-chain functionalized homopolypeptides can be used as a general platform for development of biomimetic, coacervate-forming polymers.","PeriodicalId":520914,"journal":{"name":"Polymer science & technology (Washington, D.C.)","volume":"1 1","pages":"65-72"},"PeriodicalIF":0.0,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0