Toxicology communications最新文献

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Orally-administered beta-cyclodextrin as a novel countermeasure for perfluorooctane sulfonic acid toxicity in mice. 口服-环糊精作为全氟辛烷磺酸对小鼠毒性的新对策。

IF 0.9

Toxicology communications Pub Date : 2026-02-10 DOI: 10.1080/24734306.2026.2728767

Sergey Kalinin, Andrea Saji, Rebecca Alemani, Zachary McDonald, Intakhar Ahmad, Robert Sargis, Israel Rubinstein, Douglas L Feinstein

{"title":"Orally-administered beta-cyclodextrin as a novel countermeasure for perfluorooctane sulfonic acid toxicity in mice.","authors":"Sergey Kalinin, Andrea Saji, Rebecca Alemani, Zachary McDonald, Intakhar Ahmad, Robert Sargis, Israel Rubinstein, Douglas L Feinstein","doi":"10.1080/24734306.2026.2728767","DOIUrl":"10.1080/24734306.2026.2728767","url":null,"abstract":"Introduction: Perfluoroalkyl substances (PFAS) are associated with an increased risk of several cancers, immune disorders, and neuropathology. These actions are compounded by their long half-lives.Methods: We tested if exposure to perfluorooctane sulfonic acid (PFOS) worsens disease progression or reduces survival in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, and if treatment with beta-cyclodextrin (βCD, which encapsulates PFOS) mitigated PFOS effects. Adult female C57BL/6 mice were provided drinking water containing 0 (control) or 20 μg/mL PFOS for 2 weeks, immunized to develop EAE, then provided standard chow or chow containing 2% w/w βCD.Results: Control EAE mice exhibited typical disease progression, irrespective of being on standard or βCD chow. By 10 days post immunization, PFOS-exposed EAE kept on standard chow began to die, reaching nearly 60% mortality (5/8) at day 17. In contrast, in PFOS-exposed EAE mice provided βCD chow, mortality was reduced to 12% (1/8). The quantification of plasma PFOS concentrations showed an approximately 60% reduction in βCD-treated mice compared to mice kept on standard chow.Discussion: These findings suggest that PFOS led to systemic immune dysregulation upon immunization or that EAE induction lowered the threshold for PFOS-induced mortality.Conclusion: Providing dietary βCD can accelerate PFOS clearance.","PeriodicalId":520866,"journal":{"name":"Toxicology communications","volume":"10 1","pages":"1-18"},"PeriodicalIF":0.9,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations in the cecal microbiome of New Zealand White rabbits due to the long-acting anticoagulant rodenticide brodifacoum. 长效抗凝血灭鼠剂溴化钾对新西兰大白兔盲肠微生物群的影响。

IF 0.5

Toxicology communications Pub Date : 2025-01-01 Epub Date: 2025-05-12 DOI: 10.1080/24734306.2025.2500111

Ankur Naqib, Intakhar Ahmad, Zachary McDonald, Sergey Kalinin, Jackie Rocha, Ankit Tandon, Ramanjaneyulu Rayala, Leonid Feferman, George E Chlipala, Hui Chen, Matthew Lindeblad, Israel Rubinstein, Stefan Green, Richard van Breemen, Douglas L Feinstein

{"title":"Alterations in the cecal microbiome of New Zealand White rabbits due to the long-acting anticoagulant rodenticide brodifacoum.","authors":"Ankur Naqib, Intakhar Ahmad, Zachary McDonald, Sergey Kalinin, Jackie Rocha, Ankit Tandon, Ramanjaneyulu Rayala, Leonid Feferman, George E Chlipala, Hui Chen, Matthew Lindeblad, Israel Rubinstein, Stefan Green, Richard van Breemen, Douglas L Feinstein","doi":"10.1080/24734306.2025.2500111","DOIUrl":"10.1080/24734306.2025.2500111","url":null,"abstract":"Long-acting anti-coagulant rodenticides (LAARs) are well characterized with respect to inhibition of vitamin K1 synthesis and effects on blood coagulation. However, the effects of LAARs on the microbiome have not been explored. We administered brodifacoum (BDF), one of the more potent LAARs, to adult male New Zealand White rabbits, and carried out 16S RNA sequencing on cecal samples collected after different times. Samples were also obtained from rabbits treated with the bile sequestrant cholestyramine (CSA) which accelerates BDF clearance from the body, and from CSA-only treated rabbits. Changes at both the phylum and genus levels in relative abundance were observed after 2- and 3-days exposure to BDF. The majority of those microbiota changes were prevented by co-treatment with CSA. Identification of metabolic pathways potentially altered by BDF using Picrust2 identified several L-arginine-related pathways. Exposure to BDF caused increases in plasma L-arginine concentration as well as nitrites, suggesting increased activity of nitric oxide synthase. We also observed increases due to BDF in plasma concentrations of L-arginine-related molecules including L-citrulline, L-ornithine, and methylated L-arginines. These results demonstrate that LAAR poisoning can induce microbiome dysbiosis and influence metabolic pathways and metabolites involved in inflammation and vasodilation.","PeriodicalId":520866,"journal":{"name":"Toxicology communications","volume":"9 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0