Fawzia Zakaria El-Ablack, M A Metwally, A M Khalil
{"title":"Michael Reaction of 3-aAryl-2,4-Dicarboethoxy-5-Hydroxy-5-Methylcyclohexanones.","authors":"Fawzia Zakaria El-Ablack, M A Metwally, A M Khalil","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The reaction of 3-aryl-2,4-dicarboethoxy-5-hydroxy-5-methylcyclohexanones <b>1</b>with benzalacetone, dibenzalacetone, benzalacetophenone, and 4-benzal-1-phenyl-3-methyl pyrazolone has been investigated to give Michael compounds <b>2-5</b>. hydrolysis of the dioxo derivative <b>4</b> afforded1,5-dicarbonyl derivative <b>6</b>which On condensation with hydrazine and/or substituted hydrazine and hydroxylamine produced1,2-diazepine and 1,2-oxazepine derivatives <b>7,8</b> respectively. Reaction of β-Keto ester <b>1</b> with 1,3-diphenylacetone afforded <b>9</b>. The structures of the hitherto unknown compounds have been confirmed by analytical and spectral data. The newly synthesized compounds have been screened to test their antimicrobial and antifungal activity.</p>","PeriodicalId":520861,"journal":{"name":"Organic chemistry International","volume":"5 5","pages":"311-323"},"PeriodicalIF":0.0,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}