Essential chemPub Date : 2025-01-01Epub Date: 2025-01-29DOI: 10.1080/28378083.2024.2394899
Shivangi Kharbanda, Osaid Alkhamayseh, Georgia Eastham, Jimmie D Weaver
{"title":"Synthesis of Functionalized Benzocycloheptene Analogs.","authors":"Shivangi Kharbanda, Osaid Alkhamayseh, Georgia Eastham, Jimmie D Weaver","doi":"10.1080/28378083.2024.2394899","DOIUrl":"10.1080/28378083.2024.2394899","url":null,"abstract":"<p><p>The benzocycloheptene core is structurally important motif that appears within a wide array of natural products, and benzocycloheptene has recently been demonstrated to undergo [3+2] photo-sensitized cycloaddition reactions. Thus, there is a need for efficient synthetic protocols to access this motif. Herein, we provide efficient strategies to achieve highly functionalized benzocycloheptene derivatives starting from commercially available 1-benzosuberone and 1-tetralone. We anticipate that these benzocycloheptene compounds will serve as excellent precursors for a diverse array of chemical reactions.</p>","PeriodicalId":520509,"journal":{"name":"Essential chem","volume":"2 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}