NPJ biomedical innovations最新文献

Super-lubricous polyethylene glycol hydrogel microspheres for use in knee osteoarthritis treatments. 用于膝关节骨关节炎治疗的超润滑聚乙二醇水凝胶微球。

NPJ biomedical innovations Pub Date : 2025-01-01 Epub Date: 2025-03-24 DOI: 10.1038/s44385-025-00011-3

Samuel Stealey, Ether Dharmesh, Maitreyi Bhagat, Abdul Malik Tyagi, Andrew Schab, Melissa Hong, Damon Osbourn, Yousef Abu-Amer, Paul A Jelliss, Silviya Petrova Zustiak

{"title":"Super-lubricous polyethylene glycol hydrogel microspheres for use in knee osteoarthritis treatments.","authors":"Samuel Stealey, Ether Dharmesh, Maitreyi Bhagat, Abdul Malik Tyagi, Andrew Schab, Melissa Hong, Damon Osbourn, Yousef Abu-Amer, Paul A Jelliss, Silviya Petrova Zustiak","doi":"10.1038/s44385-025-00011-3","DOIUrl":"10.1038/s44385-025-00011-3","url":null,"abstract":"Knee osteoarthritis (OA) is characterized by cartilage degeneration and significant reduction in lubrication. One strategy to recover the natural lubrication of the synovial fluid is the injection of hydrogel microspheres. Here, we have fabricated polyethylene glycol (PEG)-based hydrogel microspheres via a modified electrospraying setup. To improve throughout, crosslinking of PEG droplets was delayed until after droplet formation was complete. A custom-synthesized super-lubricious copolymer consisting of adhesive dopamine methacrylate (DMA), zwitterionic sulfobetaine methacrylate (SBMA), and fluorescent rhodamine B was used to dip-coat the PEG microspheres. Super-lubricious PEG microspheres coating reduced coefficient of friction by 57% compared to simulated synovial fluid, indicating beneficial lubrication properties. When injected into C57BL6 mice, PEG microspheres exhibited stability for up to 26 d and did not adversely affect mouse behavior. These super-lubricious PEG microspheres offer great promise to reduce the friction that is a hallmark of progressive OA, potentially mitigating the need for total knee arthroplasty.","PeriodicalId":520479,"journal":{"name":"NPJ biomedical innovations","volume":"2 1","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CT-derived functional imaging biomarkers combined with FEV1 for predicting 10-year all-cause mortality in COPDGene cohort. ct衍生的功能成像生物标志物结合FEV1预测COPDGene队列的10年全因死亡率

NPJ biomedical innovations Pub Date : 2025-01-01 Epub Date: 2025-07-04 DOI: 10.1038/s44385-025-00027-9

Girish Nair, Yuying Judy Xing, Aaron Luong, Faiza Bashar, Amanda Nowacki, Craig Stevens, Lili Zhao, Edward Castillo

{"title":"CT-derived functional imaging biomarkers combined with FEV1 for predicting 10-year all-cause mortality in COPDGene cohort.","authors":"Girish Nair, Yuying Judy Xing, Aaron Luong, Faiza Bashar, Amanda Nowacki, Craig Stevens, Lili Zhao, Edward Castillo","doi":"10.1038/s44385-025-00027-9","DOIUrl":"10.1038/s44385-025-00027-9","url":null,"abstract":"This study evaluates the predictive power of CT-derived functional imaging (CTFI) combined with forced expiratory volume in 1 second (FEV1) for 10-year all-cause mortality in COPD patients. We analyzed 8583 participants from the COPDGene® cohort, focusing on 3550 participants with spirometric obstruction. CTFI metrics, including ventilation (CT-V) and perfusion (PBM), were computed from non-contrast CT scans at lobar resolution. Our findings show that regional and global CTFI scores decline with advancing GOLD stages. A Random Survival Forest model, adjusted for age, BMI, and scanner type, demonstrated significant improvement in mortality prediction when combining FEV1 with CTFI, compared to FEV1 alone, with an AUC increase from 0.71 to 0.76 over 10 years. The Net Reclassification Index further confirmed the added predictive value of CTFI. These results suggest that integrating CTFI with traditional lung function measures enhances mortality prediction in COPD, offering a promising tool for clinical risk assessment.","PeriodicalId":520479,"journal":{"name":"NPJ biomedical innovations","volume":"2 1","pages":"25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stick-and-play bioadhesive hairlike electrodes for chronic EEG recording on human. 用于人体慢性脑电图记录的可贴即用生物胶发状电极。

NPJ biomedical innovations Pub Date : 2025-01-01 Epub Date: 2025-03-18 DOI: 10.1038/s44385-025-00009-x

Salahuddin Ahmed, Marzia Momin, Jiashu Ren, Hyunjin Lee, Basma AlMahmood, Li-Pang Huang, Archana Pandiyan, Loganathan Veeramuthu, Chi-Ching Kuo, Tao Zhou

{"title":"Stick-and-play bioadhesive hairlike electrodes for chronic EEG recording on human.","authors":"Salahuddin Ahmed, Marzia Momin, Jiashu Ren, Hyunjin Lee, Basma AlMahmood, Li-Pang Huang, Archana Pandiyan, Loganathan Veeramuthu, Chi-Ching Kuo, Tao Zhou","doi":"10.1038/s44385-025-00009-x","DOIUrl":"10.1038/s44385-025-00009-x","url":null,"abstract":"Chronic high-fidelity electroencephalogram (EEG) recording faces challenges due to weak EEG signals and presence of hair, which create interfacial gaps and motion artifacts. To ensure reliable EEG recording, stable connection between electrodes and the scalp is essential. Metallic electrodes with electrolyte gel are commonly used, but their stability is often affected by gel drying and inconsistent electrode positioning across sessions. Here, we report stick-and-play hairlike device that can attach to the human scalp without the need for skin preparation, using a highly flexible and stretchable electrode material and robust bioadhesive material. The hairlike device can be worn for long term without being noticeable, maintaining a stable skin adhesion and interface impedance across different recording sessions and hundred cycles of cyclic loading. The design, which mimics human hair, makes it indistinguishable from a natural look. Additionally, the hairlike device has been demonstrated as an efficient medium for long-term, high-quality EEG recordings.","PeriodicalId":520479,"journal":{"name":"NPJ biomedical innovations","volume":"2 1","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A biosynthetic thumb prosthesis. 生物合成拇指假体。

NPJ biomedical innovations Pub Date : 2025-01-01 Epub Date: 2025-07-02 DOI: 10.1038/s44385-025-00031-z

Sachi Bansal, Gracia V Lai, Marcus Belingheri, Amber Q Kashay, Jinyoung Kim, Alyssa Tomkinson, Samantha Herman, Keval Bollavaram, Brian K Zukotynski, Sean Thomas, Nirbhay S Jain, Kodi K Azari, Lauren E Wessel, Tyler R Clites

{"title":"A biosynthetic thumb prosthesis.","authors":"Sachi Bansal, Gracia V Lai, Marcus Belingheri, Amber Q Kashay, Jinyoung Kim, Alyssa Tomkinson, Samantha Herman, Keval Bollavaram, Brian K Zukotynski, Sean Thomas, Nirbhay S Jain, Kodi K Azari, Lauren E Wessel, Tyler R Clites","doi":"10.1038/s44385-025-00031-z","DOIUrl":"10.1038/s44385-025-00031-z","url":null,"abstract":"In cases of severe damage to the extremities, the function and structure of compromised tissues must be replaced. If biological reconstruction using autologous tissue is not feasible, amputation and replacement with a synthetic prosthesis is often the next best option. Synthetic prostheses are limited, especially in their ability to restore skin sensation. Here we show a biosynthetic prosthesis that combines the versatility of titanium with the rich sensory capabilities of biological skin. The prosthesis recreates opposition pinch by linking motion of the prosthetic joint to that of the residual biological joint, and is enclosed in neurotized skin from the patient's own body. We validated the biosynthetic thumb's mechanical function on the benchtop and in a cadaver, and showed viability of the skin interface in an animal model. These results provide a framework for functional reconstruction of amputated digits using a combination of synthetic materials and biological tissues.","PeriodicalId":520479,"journal":{"name":"NPJ biomedical innovations","volume":"2 1","pages":"22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-invasive detection of instantaneous fetal hypoxemia in large animal model of pregnancy. 大型妊娠动物模型瞬时胎儿低氧血症的无创检测。

NPJ biomedical innovations Pub Date : 2025-01-01 Epub Date: 2025-04-23 DOI: 10.1038/s44385-025-00014-0

Weitai Qian, Mahya Saffarpour, Rishad R Joarder, Begum Kasap, Kourosh Vali, Tailai Lihe, Herman L Hedriana, Aijun Wang, Diana Farmer, Soheil Ghiasi

{"title":"Non-invasive detection of instantaneous fetal hypoxemia in large animal model of pregnancy.","authors":"Weitai Qian, Mahya Saffarpour, Rishad R Joarder, Begum Kasap, Kourosh Vali, Tailai Lihe, Herman L Hedriana, Aijun Wang, Diana Farmer, Soheil Ghiasi","doi":"10.1038/s44385-025-00014-0","DOIUrl":"https://doi.org/10.1038/s44385-025-00014-0","url":null,"abstract":"Cardiotocography (CTG) has a high false positive rate for the detection of babies at risk of birth asphyxia. Transabdominal Fetal Pulse Oximetry (TFO) has the potential to supplement CTG by enabling non-invasive measurement of fetal arterial blood oxygen saturation (fSpO2). Previous attempts at TFO were limited to intermittent measurements using highly specialized and precise instruments. We present a TFO system, utilizing multiple commodity silicon photo-detectors to acquire mixed maternal-fetal PPG signals, for non-invasive and continuous detection of fetal instantaneous normoxia vs. hypoxemia status, relative to a user-specified threshold. Data from controlled de-saturation experiments using pregnant ewes with an in-utero hypoxic lamb model, from a total of n = 8 hypoxic rounds (length = 34.5 ± 12 min), is used to validate the technology. The multi-layer perceptron model is used for information fusion, and fetal arterial blood oxygen saturation obtained from blood gas analysis is used as a gold standard. The method detects instantaneous hypoxemia (fSpO2 <30%) with 87.6% accuracy. Cross-validation shows an average sensitivity of 88.2% and specificity of 71.2%. The receiver operating characteristic (ROC) curves showed strong discrimination abilities in all cross-validation iterations (AUC = 0.87). This study underscores TFO's promise for accurate detection of instantaneous fetal hypoxemia relative to a user-defined threshold value, and for contribution to enhancement of intrapartum fetal monitoring in the longer term.","PeriodicalId":520479,"journal":{"name":"NPJ biomedical innovations","volume":"2 1","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of collagen type I-based hydrogels: focus on composition-structure-properties relationships. ⅰ型胶原基水凝胶研究进展：主要研究成分-结构-性能关系。

NPJ biomedical innovations Pub Date : 2025-01-01 Epub Date: 2025-05-03 DOI: 10.1038/s44385-025-00018-w

Mariana Pires Figueiredo, Silvia Rodríguez-Fernández, Francesco Copes, Diego Mantovani

引用次数: 0

PodGPT: an audio-augmented large language model for research and education. PodGPT：用于研究和教育的音频增强大型语言模型。

NPJ biomedical innovations Pub Date : 2025-01-01 Epub Date: 2025-07-07 DOI: 10.1038/s44385-025-00022-0

Shuyue Jia, Subhrangshu Bit, Edward Searls, Meagan V Lauber, Pengrui Fan, William M Wang, Lindsey A Claus, Varuna H Jasodanand, Divya Veerapaneni, Rhoda Au, Vijaya B Kolachalama

{"title":"PodGPT: an audio-augmented large language model for research and education.","authors":"Shuyue Jia, Subhrangshu Bit, Edward Searls, Meagan V Lauber, Pengrui Fan, William M Wang, Lindsey A Claus, Varuna H Jasodanand, Divya Veerapaneni, Rhoda Au, Vijaya B Kolachalama","doi":"10.1038/s44385-025-00022-0","DOIUrl":"10.1038/s44385-025-00022-0","url":null,"abstract":"The proliferation of scientific podcasts has generated an extensive repository of educational content, rich in specialized terminology, diverse topics, and expert dialogues. Here, we introduce a computational framework designed to enhance large language models by leveraging this informational content from publicly accessible audio podcasts across science, technology, engineering, mathematics, and medicine (STEMM). This dataset, comprising over 3700 hours of audio content, was transcribed to generate over 42 million text tokens. Our model, PodGPT, integrates this wealth of complex dialogue found in audio podcasts to improve understanding of natural language nuances, cultural contexts, as well as scientific and medical knowledge. PodGPT also employs retrieval augmented generation (RAG) on a vector database, providing real-time access to emerging scientific literature. Evaluated on multiple benchmarks, PodGPT demonstrated an average improvement of 1.82 percentage points over standard open-source benchmarks and 2.43 percentage points when augmented with evidence from the RAG pipeline. Moreover, it showcased an average improvement of 1.18 percentage points in its zero-shot multilingual transfer ability, effectively generalizing to different linguistic contexts. By harnessing the untapped potential of podcast content, PodGPT advances natural language processing and conversational AI, offering enhanced capabilities for STEMM research and education.","PeriodicalId":520479,"journal":{"name":"NPJ biomedical innovations","volume":"2 1","pages":"26"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12234354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biocompatibility of decellularized spinach leaves. 脱细胞菠菜叶的生物相容性。

NPJ biomedical innovations Pub Date : 2025-01-01 Epub Date: 2025-07-02 DOI: 10.1038/s44385-025-00028-8

Joshua R Gershlak, Cole K Burgess, Gianluca Fontana, Luke R Perreault, Richard Thyden, Lauren A Shrem, Antonio C F Dos Santos, Pamela J Weathers, Tanja Dominko, William L Murphy, Glenn R Gaudette

{"title":"Biocompatibility of decellularized spinach leaves.","authors":"Joshua R Gershlak, Cole K Burgess, Gianluca Fontana, Luke R Perreault, Richard Thyden, Lauren A Shrem, Antonio C F Dos Santos, Pamela J Weathers, Tanja Dominko, William L Murphy, Glenn R Gaudette","doi":"10.1038/s44385-025-00028-8","DOIUrl":"10.1038/s44385-025-00028-8","url":null,"abstract":"Previously, we demonstrated the potential of decellularized spinach leaves to act as prevascularized scaffolds for tissue engineering. In this follow-up study, we aim to further probe this technology's efficacy through investigation of leaf scaffold biocompatibility. Decellularization protocols were modified to limit possible toxicity by lowering the time and concentration of detergents used. Decellularized leaves that were processed with this modified technique were found to have limited effects on cell viability in a leaching assay. To evaluate biocompatibility, decellularized leaves were implanted subcutaneously in Sprague Dawley rats. Leaves maintained a limited immunological response 4 weeks post-implantation. A separate group of decellularized leaves were pre-functionalized with an RGD-dopamine peptide and subsequently implanted. These functionalized leaf implants integrated into the host tissue within 1-week, with visible rat collagen deposition found within the leaf scaffold. These findings further demonstrate the suitability of leaves as scaffolding for tissue engineering and suggest exploration for clinical use.","PeriodicalId":520479,"journal":{"name":"NPJ biomedical innovations","volume":"2 1","pages":"23"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0