NPJ biomedical innovations最新文献

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Super-lubricous polyethylene glycol hydrogel microspheres for use in knee osteoarthritis treatments.

NPJ biomedical innovations Pub Date : 2025-01-01 Epub Date: 2025-03-24 DOI: 10.1038/s44385-025-00011-3

Samuel Stealey, Ether Dharmesh, Maitreyi Bhagat, Abdul Malik Tyagi, Andrew Schab, Melissa Hong, Damon Osbourn, Yousef Abu-Amer, Paul A Jelliss, Silviya Petrova Zustiak

{"title":"Super-lubricous polyethylene glycol hydrogel microspheres for use in knee osteoarthritis treatments.","authors":"Samuel Stealey, Ether Dharmesh, Maitreyi Bhagat, Abdul Malik Tyagi, Andrew Schab, Melissa Hong, Damon Osbourn, Yousef Abu-Amer, Paul A Jelliss, Silviya Petrova Zustiak","doi":"10.1038/s44385-025-00011-3","DOIUrl":"10.1038/s44385-025-00011-3","url":null,"abstract":"Knee osteoarthritis (OA) is characterized by cartilage degeneration and significant reduction in lubrication. One strategy to recover the natural lubrication of the synovial fluid is the injection of hydrogel microspheres. Here, we have fabricated polyethylene glycol (PEG)-based hydrogel microspheres via a modified electrospraying setup. To improve throughout, crosslinking of PEG droplets was delayed until after droplet formation was complete. A custom-synthesized super-lubricious copolymer consisting of adhesive dopamine methacrylate (DMA), zwitterionic sulfobetaine methacrylate (SBMA), and fluorescent rhodamine B was used to dip-coat the PEG microspheres. Super-lubricious PEG microspheres coating reduced coefficient of friction by 57% compared to simulated synovial fluid, indicating beneficial lubrication properties. When injected into C57BL6 mice, PEG microspheres exhibited stability for up to 26 d and did not adversely affect mouse behavior. These super-lubricious PEG microspheres offer great promise to reduce the friction that is a hallmark of progressive OA, potentially mitigating the need for total knee arthroplasty.","PeriodicalId":520479,"journal":{"name":"NPJ biomedical innovations","volume":"2 1","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stick-and-play bioadhesive hairlike electrodes for chronic EEG recording on human.

NPJ biomedical innovations Pub Date : 2025-01-01 Epub Date: 2025-03-18 DOI: 10.1038/s44385-025-00009-x

Salahuddin Ahmed, Marzia Momin, Jiashu Ren, Hyunjin Lee, Basma AlMahmood, Li-Pang Huang, Archana Pandiyan, Loganathan Veeramuthu, Chi-Ching Kuo, Tao Zhou

{"title":"Stick-and-play bioadhesive hairlike electrodes for chronic EEG recording on human.","authors":"Salahuddin Ahmed, Marzia Momin, Jiashu Ren, Hyunjin Lee, Basma AlMahmood, Li-Pang Huang, Archana Pandiyan, Loganathan Veeramuthu, Chi-Ching Kuo, Tao Zhou","doi":"10.1038/s44385-025-00009-x","DOIUrl":"10.1038/s44385-025-00009-x","url":null,"abstract":"Chronic high-fidelity electroencephalogram (EEG) recording faces challenges due to weak EEG signals and presence of hair, which create interfacial gaps and motion artifacts. To ensure reliable EEG recording, stable connection between electrodes and the scalp is essential. Metallic electrodes with electrolyte gel are commonly used, but their stability is often affected by gel drying and inconsistent electrode positioning across sessions. Here, we report stick-and-play hairlike device that can attach to the human scalp without the need for skin preparation, using a highly flexible and stretchable electrode material and robust bioadhesive material. The hairlike device can be worn for long term without being noticeable, maintaining a stable skin adhesion and interface impedance across different recording sessions and hundred cycles of cyclic loading. The design, which mimics human hair, makes it indistinguishable from a natural look. Additionally, the hairlike device has been demonstrated as an efficient medium for long-term, high-quality EEG recordings.","PeriodicalId":520479,"journal":{"name":"NPJ biomedical innovations","volume":"2 1","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0