Journal of clinical & cellular immunology最新文献

筛选
英文 中文
Hotairm1 Controls S100A9 Protein Phosphorylation in Myeloid-Derived Suppressor Cells during Sepsis. Hotairm1控制脓毒症期间髓源性抑制细胞中S100A9蛋白磷酸化。
Journal of clinical & cellular immunology Pub Date : 2023-01-01 Epub Date: 2023-08-03
Isatou Bah, Dima Youssef, Zhi Q Yao, Charles E McCall, Mohamed El Gazzar
{"title":"Hotairm1 Controls S100A9 Protein Phosphorylation in Myeloid-Derived Suppressor Cells during Sepsis.","authors":"Isatou Bah, Dima Youssef, Zhi Q Yao, Charles E McCall, Mohamed El Gazzar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>During the acute phase of sepsis, the S100A9 proinflammatory protein resides in the cytosol in a phosphorylated form. In contrast, S100A9 relocalizes to the nucleus in an unphosphorylated form during the late/chronic sepsis state of immunometabolic paralysis. We reported that Hotairm1, a long noncoding RNA, facilitates S100A9 nuclear location in myeloid-derived suppressor cells. Here, we show that Hotairm1 promotes S100A9 nuclear location by limiting its phosphorylation by p38 MAPK. Knockdown of Hotairm1 in MDSCs from mice and humans with late sepsis increases phospho-S100A9 protein. Conversely, increasing Hotairm1 in early sepsis Gr1<sup>+</sup>CD11b<sup>+</sup> cells by transfection decreases phospho-S100A9 protein levels. Notably, increasing S100A9 protein phosphorylation in late sepsis MDSCs <i>via</i> Hotairm1 knockdown decreases the production of the immunosuppressive cytokine IL-10. These results suggest that targeting Hotairm1 might reduce MDSC expansion during sepsis and thus relieve immunosuppression and improve survival.</p>","PeriodicalId":520327,"journal":{"name":"Journal of clinical & cellular immunology","volume":"14 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信