Advances in radiotherapy & nuclear medicine最新文献

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Breast cancer radiotherapy and the risk of lung injury: Advances and perspectives. 乳腺癌放疗与肺损伤风险：进展与展望。

Advances in radiotherapy & nuclear medicine Pub Date : 2026-01-21 DOI: 10.36922/arnm025340041

Shubhankar Suman

{"title":"Breast cancer radiotherapy and the risk of lung injury: Advances and perspectives.","authors":"Shubhankar Suman","doi":"10.36922/arnm025340041","DOIUrl":"10.36922/arnm025340041","url":null,"abstract":"Breast cancer is the most prevalent malignancy among women worldwide, and radiotherapy (RT) plays a central role in reducing local recurrence and improving survival. Technological advances such as three-dimensional conformal RT (3D-CRT), intensity-modulated RT (IMRT), volumetric-modulated arc therapy (VMAT), and particle therapies have enhanced dose conformity and reduced exposure to surrounding healthy tissues, particularly the lungs. Nevertheless, radiation-induced lung injury (RILI) remains a clinically relevant concern because of the close anatomical relationship between the breast and lung. RILI is a biphasic process, comprising early radiation pneumonitis and late radiation-induced pulmonary fibrosis, with severity influenced by dose distribution and treatment modality. While 3D-CRT carries a moderate risk due to limited beam modulation, IMRT and VMAT improve target coverage but may increase low-dose exposure to larger lung volumes, potentially increasing the risks of subclinical injury and, in the long term, secondary malignancy. Adjunctive lung-sparing strategies, including deep inspiration breath-hold and image-guided techniques, further reduce pulmonary dose. Proton beam therapy, particularly pencil beam scanning, offers additional lung protection through Bragg peak-based dose deposition, minimizing exit dose and irradiation of non-target tissues. Early clinical data suggest a lower incidence of RILI with PBT, although long-term outcomes remain under investigation. Carbon ion RT remains investigational in breast cancer. This review summarizes current evidence on RILI risk across modern RT modalities. A deeper understanding of modality-specific risks is essential for guiding personalized treatment planning and implementing effective lung-sparing strategies.","PeriodicalId":520275,"journal":{"name":"Advances in radiotherapy & nuclear medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146109358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combining PET and Compton imaging with edge-on CZT detectors for enhanced diagnostic capabilities. 将 PET 和康普顿成像与边缘 CZT 探测器相结合，增强诊断能力。

Advances in radiotherapy & nuclear medicine Pub Date : 2024-06-28 Epub Date: 2024-06-14 DOI: 10.36922/arnm.3330

Greyson Shoop, Shiva Abbaszadeh

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引用次数: 0