Microbiota in health and disease最新文献

{"title":"The prevalence and risk factors of <i>Helicobacter pylori</i> infection and <i>cagA</i> virulence gene carriage in adults in the Navajo Nation.","authors":"Dornell Pete, Nina R Salama, Johanna W Lampe, Michael C Wu, Amanda I Phipps","doi":"10.26355/mhd_20247_1007","DOIUrl":"10.26355/mhd_20247_1007","url":null,"abstract":"<p><strong>Background: </strong>American Indian and Alaska Native people in the United States experience high rates of stomach cancer. <i>Helicobacter pylori</i> infection is a significant risk factor for stomach cancer, and <i>H. pylori</i> strains that carry the <i>cagA</i> gene are linked to greater gastrointestinal disease severity. Yet, little is known about <i>H. pylori</i> and <i>cagA</i> infections in American Indian and Alaska Native people, particularly at the tribal level. We assessed the prevalence and risk factors of <i>H. pylori</i> infection and <i>cagA</i> gene carriage in tribal members from the Navajo Nation.</p><p><strong>Materials and methods: </strong>We conducted a cross-sectional study with adults from the Navajo Nation. Stool samples collected from participants were analyzed with droplet digital PCR for <i>H. pylori</i> 16S ribosomal and <i>cagA</i> virulence genes. Self-administered health and food questionnaires were mailed to participants to collect information on sociodemographic, health, lifestyle, and environmental risk factors for <i>H. pylori</i> infection. Logistic regression assessed the association between risk factors and <i>H. pylori</i> infection and <i>cagA</i> gene carriage.</p><p><strong>Results: </strong>Among 99 adults, the median age was 45 (age range: 18 to 79 years), and 73.7% were female. About 56.6% (95% CI: 46.2-66.5) of participants were infected with <i>H. pylori</i>. Of <i>H. pylori</i>-infected participants, 78.6% (95% CI: 65.6-88.4) were <i>cagA</i>-gene positive. No significant associations of relevant risk factors with <i>H. pylori</i> and <i>cagA</i>-gene positive infections were noted.</p><p><strong>Conclusions: </strong>In a community-based study population, a substantial proportion of adult tribal members had <i>H. pylori</i> and <i>cagA</i>-gene positive infections. Given these high proportions, culturally appropriate prevention strategies and interventions addressing <i>H. pylori</i> infections present an avenue for additional research and stomach cancer prevention in the Navajo Nation.</p>","PeriodicalId":519997,"journal":{"name":"Microbiota in health and disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11282893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}