Societe internationale d'urologie journal : SIUJ最新文献

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2022 WUOF/SIU International Consultation on Urological Diseases: Active Surveillance for Small Renal Masses. 2022 年世界泌尿外科联合会/国际泌尿外科联盟泌尿系统疾病国际协商会议：主动监测肾小肿块。

Societe internationale d'urologie journal : SIUJ Pub Date : 2022-11-01 DOI: 10.48083/oses5540

Eric C Kauffman, Mark W Ball, Ravi Barod, Umberto Capitanio, Antonio Finelli, M Carmen Mir, Brian Shuch, Marc C Smaldone, Maxine G B Tran, Phillip M Pierorazio

{"title":"2022 WUOF/SIU International Consultation on Urological Diseases: Active Surveillance for Small Renal Masses.","authors":"Eric C Kauffman, Mark W Ball, Ravi Barod, Umberto Capitanio, Antonio Finelli, M Carmen Mir, Brian Shuch, Marc C Smaldone, Maxine G B Tran, Phillip M Pierorazio","doi":"10.48083/oses5540","DOIUrl":"10.48083/oses5540","url":null,"abstract":"With greater awareness of indolence underlying small renal masses (SRM ≤ 4 cm) and the morbidity of invasive treatment, active surveillance for SRM patients is being increasingly utilized on an international level. This synopsis summarizes the 2022 review and expert opinion recommendations provided to the International Consultation of Urological Diseases (ICUD) by 10 urologists from high-volume active surveillance practices at international centers. Topics reviewed include SRM biology and clinical behavior, current national and international guidelines for active surveillance of SRM patients, active surveillance utilization patterns and barriers to implementation, outcomes and limitations of the active surveillance literature, criteria for active surveillance patient selection, protocols for active surveillance management including frequency/modality of imaging and the role of renal tumor biopsy, triggers for delayed intervention during active surveillance including tumor factors and patient factors, and pathological outcomes of delayed intervention. We conclude that despite limitations of the current literature, active surveillance is a safe initial management strategy for many SRM patients. The slow growth and low metastatic potential of SRMs, combined with no evidence to suggest oncologic compromise with delay to treatment, should provide confidence to both patients and providers who are considering active surveillance. Future research for prioritization should include characterization of long-term active surveillance outcomes including rates of metastasis and delayed intervention, standardization of objective tumor progression criteria for triggering delayed intervention, and further delineation of the role for active surveillance in young and healthy patients.","PeriodicalId":519933,"journal":{"name":"Societe internationale d'urologie journal : SIUJ","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2022 WUOF/SIU International Consultation on Urological Diseases: Genetics and Tumor Microenvironment of Renal Cell Carcinoma. 2022 年世界泌尿系统疾病联合会/国际泌尿系统疾病学会国际泌尿系统疾病磋商会议：肾细胞癌的遗传学和肿瘤微环境。

Societe internationale d'urologie journal : SIUJ Pub Date : 2022-11-01 DOI: 10.48083/BLPV3411

Sari Khaleel, Christopher Ricketts, W Marston Linehan, Mark Ball, Brandon Manley, Samra Turajilic, James Brugarolas, Ari Hakimi

{"title":"2022 WUOF/SIU International Consultation on Urological Diseases: Genetics and Tumor Microenvironment of Renal Cell Carcinoma.","authors":"Sari Khaleel, Christopher Ricketts, W Marston Linehan, Mark Ball, Brandon Manley, Samra Turajilic, James Brugarolas, Ari Hakimi","doi":"10.48083/BLPV3411","DOIUrl":"10.48083/BLPV3411","url":null,"abstract":"Renal cell carcinoma is a diverse group of diseases that can be distinguished by distinct histopathologic and genomic features. In this comprehensive review, we highlight recent advancements in our understanding of the genetic and microenvironmental hallmarks of kidney cancer. We begin with clear cell renal cell carcinoma (ccRCC), the most common subtype of this disease. We review the chromosomal and genetic alterations that drive initiation and progression of ccRCC, which has recently been shown to follow multiple highly conserved evolutionary trajectories that in turn impact disease progression and prognosis. We also review the diverse genetic events that define the many recently recognized rare subtypes within non-clear cell RCC. Finally, we discuss our evolving understanding of the ccRCC microenvironment, which has been revolutionized by recent bulk and single-cell transcriptomic analyses, suggesting potential biomarkers for guiding systemic therapy in the management of advanced ccRCC.","PeriodicalId":519933,"journal":{"name":"Societe internationale d'urologie journal : SIUJ","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141263666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0