The International Journal of Biological Markers最新文献

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Human epididymal protein 4 and its combined detection show good diagnostic value in lung cancer: A retrospective study 人类附睾蛋白 4 及其联合检测对肺癌具有良好的诊断价值：一项回顾性研究

The International Journal of Biological Markers Pub Date : 2024-04-15 DOI: 10.1177/03936155241244802

Lifang Wu, Xiang Chen, Tingting Peng, Enyan Tang, Wenjing Bai, Liya Chen

{"title":"Human epididymal protein 4 and its combined detection show good diagnostic value in lung cancer: A retrospective study","authors":"Lifang Wu, Xiang Chen, Tingting Peng, Enyan Tang, Wenjing Bai, Liya Chen","doi":"10.1177/03936155241244802","DOIUrl":"https://doi.org/10.1177/03936155241244802","url":null,"abstract":"ObjectivesThis study aimed to assess the diagnostic value of human epididymal protein 4 (HE4), a potential novel biomarker for lung cancer, and its combined detection with five other conventional biomarkers in lung cancer diagnosis and subtyping.MethodsIn this retrospective study, 115 lung cancer patients, 50 patients with benign pulmonary disease, and 50 healthy controls were included. Serum HE4, progastrin-releasing peptide (ProGRP), squamous cell carcinoma (SCC) antigen, cytokeratin-19 fragment (CYFRA21-1), neuron-specific enolase (NSE), and carcinoembryonic antigen (CEA) were analyzed using the electrochemiluminescence immunoassay and chemiluminescence immunoassay. The receiver operating characteristic curve was performed to analyze the diagnostic efficacy of individual biomarkers in identifying both lung cancer and its histologic subtypes.ResultsAll six biomarkers showed significantly elevated levels in the lung cancer group compared to both benign pulmonary disease and control groups ( P < 0.05). Among the biomarkers evaluated, HE4 exhibited the highest diagnostic performance for lung cancer, lung adenocarcinoma, and lung squamous cell carcinoma with area under the curve (AUC) values of 0.921, 0.891, and 0.937, respectively. ProGRP was the optimal biomarker for small cell lung cancer with an AUC of 0.973. The combination of all six biomarkers yielded the largest AUCs in the diagnosis of lung cancer subtypes (0.937 for lung adenocarcinoma, 0.998 for lung squamous cell carcinoma, and 0.985 for small cell lung cancer). Furthermore, specific combinations, such as HE4 + CEA, HE4 + SCC, and ProGRP + HE4 + NSE, showed strong diagnostic performance in lung cancer.ConclusionsHE4 and its combined detection held substantial clinical significance in the diagnosis of lung cancer and its histologic subtyping, especially for lung adenocarcinoma and lung squamous cell carcinoma.","PeriodicalId":519227,"journal":{"name":"The International Journal of Biological Markers","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140603509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review of biobanks in Latin America: Strengths and limitations for biomedical research 拉丁美洲生物库系统回顾：生物医学研究的优势和局限性

The International Journal of Biological Markers Pub Date : 2024-04-13 DOI: 10.1177/03936155241239672

J. Adrián Rivera-Alcántara, Natalia Esparza-Hurtado, Gabriela A. Galán-Ramírez, Ivette Cruz-Bautista, Roopa Mehta, Carlos A. Aguilar-Salinas, Alexandro J. Martagon

{"title":"A systematic review of biobanks in Latin America: Strengths and limitations for biomedical research","authors":"J. Adrián Rivera-Alcántara, Natalia Esparza-Hurtado, Gabriela A. Galán-Ramírez, Ivette Cruz-Bautista, Roopa Mehta, Carlos A. Aguilar-Salinas, Alexandro J. Martagon","doi":"10.1177/03936155241239672","DOIUrl":"https://doi.org/10.1177/03936155241239672","url":null,"abstract":"Biobanks are valuable tools for developing and applying scientific research and international cooperation through the collection of biological materials and their associated data. Systematic research following the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines was conducted in late 2022 in PubMed and Scopus, and generated 17 articles to be reviewed in depth and critically assessed using the Critical Appraisal Skills Programme Checklist due to the limited available data; 12 relevant health organizations and government websites outside of peer-reviewed journals were also included. Our research identified 44 biobanks in Latin America. In general, there is a lack of regulation and legislation guaranteeing the stored materials’ quality and institutional collaboration. We believe a consensus needs to be reached regarding the terminology and definitions used for biobanks. The design for informed consent should also be agreed upon to ensure the privacy of the data shared among institutions. In conclusion, in Latin America, there is a clear need for government support in creating specific procedures for biobanks and providing further support for existing biobanks.","PeriodicalId":519227,"journal":{"name":"The International Journal of Biological Markers","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140603508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0