The International Journal of Artificial Organs最新文献

Impact of extracorporeal hemadsorption on mortality in critically ill COVID-19 patients in the intensive care unit 体外血液吸附对重症监护室 COVID-19 重症患者死亡率的影响

The International Journal of Artificial Organs Pub Date : 2024-09-14 DOI: 10.1177/03913988241269527

Özlem Çakin, Melike Yüce Aktepe, Orbay Harmandar, Kamil Deveci, Özlem Esra Yildirim, Erdal Kurtoğlu

{"title":"Impact of extracorporeal hemadsorption on mortality in critically ill COVID-19 patients in the intensive care unit","authors":"Özlem Çakin, Melike Yüce Aktepe, Orbay Harmandar, Kamil Deveci, Özlem Esra Yildirim, Erdal Kurtoğlu","doi":"10.1177/03913988241269527","DOIUrl":"https://doi.org/10.1177/03913988241269527","url":null,"abstract":"Background:The consequences of COVID-19, such as respiratory failure and mortality, require the search for fast and effective solutions. The aim of this retrospective study is to determine the effect of extracorporeal hemadsorption on mortality in severe COVID-19 cases hospitalized in the intensive care unit (ICU).Methods:Our study is retrospective, single-center, and observational. The study included ICU patients diagnosed with COVID-19 who received extracorporeal hemadsorption treatment between March 2020 and December 2020. Effects on mortality were examined by comparing pre- and post-hemadsorption values.Results:Seventeen patients were included in the study. The mortality rate in the study was 64.7%. After hemadsorption, an increase was observed in the lymphocyte numbers, APACHE-II, and SOFA values of the patients ( p = 0.026, 0.043, and 0.033; respectively). A significant decrease was observed in CRP and fibrinogen levels ( p = 0.003 and 0.005; respectively). In the non-surviving patient group, APACHE-II, SOFA, and procalcitonin values were found to be high before and after the procedure ( p = 0.002, 0.048, and 0.06; respectively).Conclusion:In COVID-19 patients, APACHE-II and SOFA scores may be useful in predicting the effectiveness of extracorporeal hemadsorption. Our study found that patients with higher APACHE-II and SOFA scores at baseline had a higher mortality rate after hemadsorption. These findings show that the use of intensive care scoring systems may be useful in determining which patients should receive extracorporeal hemadsorption and that hemadsorption should be performed in the early stages of the disease.","PeriodicalId":519226,"journal":{"name":"The International Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142263521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Premorbid functional status in patients requiring veno-arterial extracorporeal membrane oxygenation after cardiac surgery 心脏手术后需要静脉-动脉体外膜氧合患者的病前功能状态

The International Journal of Artificial Organs Pub Date : 2024-05-02 DOI: 10.1177/03913988241247652

AlleaBelle Bradshaw, Jessica Briscoe, Kavya Sanghavi, Blake Taurone, Nidhi Vantair, Jacob Gilbreth, Akram M Zaaqoq

引用次数: 0

Silk fibroin sponge impregnated with fish bone collagen: A promising wound healing scaffold and skin tissue regeneration 浸渍鱼骨胶原蛋白的蚕丝纤维海绵：有望实现伤口愈合和皮肤组织再生的支架

The International Journal of Artificial Organs Pub Date : 2024-05-02 DOI: 10.1177/03913988241249296

Rethinam Senthil

引用次数: 0

Enhancing cutaneous wound healing: A study on the beneficial effects of nano-gelatin scaffold in rat models 促进皮肤伤口愈合：纳米明胶支架对大鼠模型有益影响的研究

The International Journal of Artificial Organs Pub Date : 2024-04-16 DOI: 10.1177/03913988241244661

Jason Sun, Yi-Chung Lai, Yi-Wen Lin, Chih-Hsiang Fang, Jui-Sheng Sun

{"title":"Enhancing cutaneous wound healing: A study on the beneficial effects of nano-gelatin scaffold in rat models","authors":"Jason Sun, Yi-Chung Lai, Yi-Wen Lin, Chih-Hsiang Fang, Jui-Sheng Sun","doi":"10.1177/03913988241244661","DOIUrl":"https://doi.org/10.1177/03913988241244661","url":null,"abstract":"The challenges in achieving optimal outcomes for wound healing have persisted for decades, prompting ongoing exploration of interventions and management strategies. This study focuses on assessing the potential benefits of implementing a nano-gelatin scaffold for wound healing. Using a rat skin defect model, full-thickness incisional wounds were created on each side of the thoracic-lumbar regions after anesthesia. The wounds were left un-sutured, with one side covered by a gelatin nano-fibrous membrane and the other left uncovered. Wound size changes were measured on days 1, 4, 7, and 14, and on day 14, rats were sacrificed for tissue sample excision, examined with hematoxylin and eosin, and Masson’s trichrome stain. Statistical comparisons were performed. The gelatin nanofibers exhibited a smooth surface with a fiber diameter of 260 ± 40 nm and porous structures with proper interconnectivity. Throughout the 14-day experimental period, significant differences in the percentage of wound closure were observed between the groups. Histological scores were higher in the experiment group, indicating less inflammation but dense and well-aligned collagen fiber formation. A preliminary clinical trial on diabetic ulcers also demonstrated promising results. This study highlights the potential of the nano-collagen fibrous membrane to reduce inflammatory infiltration and enhance fibroblast differentiation into myofibroblasts during the early stages of cutaneous wound healing. The nano-fibrous collagen membrane emerges as a promising candidate for promoting wound healing, with considerable potential for future therapeutic applications.","PeriodicalId":519226,"journal":{"name":"The International Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140603519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do medical devices contribute to sustainability? Environmental, societal and governance aspects 医疗设备是否有助于可持续发展？环境、社会和治理方面

The International Journal of Artificial Organs Pub Date : 2024-04-16 DOI: 10.1177/03913988241245015

Carlo Boccato, Jörg Vienken

{"title":"Do medical devices contribute to sustainability? Environmental, societal and governance aspects","authors":"Carlo Boccato, Jörg Vienken","doi":"10.1177/03913988241245015","DOIUrl":"https://doi.org/10.1177/03913988241245015","url":null,"abstract":"Sustainability of a product or device is currently primarily related to its environmental footprint. Here, a wider concept of sustainability is introduced for medical devices and their components in healthcare provision. Such devices sustain healthcare and patient wellbeing due to their quality specifications for material composition, product design and performance. The term quality must be intended in the most comprehensive term, including purity and biocompatibility of materials, device reliability, limited number of recalls and reduced risks as well as acceptability for patients. A close look on medical device specification shows, however, that additional parameters, such as societal, demographic and economic factors also determine medical device sustainability. The medical device life cycle, from design phase, production process to clinical application and the final disposal, also determines its impact. Recommendations for healthcare operators and managers will complete the hypothesis of this paper, that a thoroughly outlined device choice and operation together with a careful waste management of spent medical devices and their components positively affects medical device sustainability. As an example, the limited quantity of wastes and the reduced risks for adverse reaction have a positive impact on both the environmental pollution and on the costs sustained by the healthcare organisations and by the community. These factors determine both, the success of healthcare manoeuvres and the related environmental footprint.","PeriodicalId":519226,"journal":{"name":"The International Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140617972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do medical devices contribute to sustainability? The role of innovative polymers and device design 医疗器械是否有助于可持续发展？创新聚合物和设备设计的作用

The International Journal of Artificial Organs Pub Date : 2024-04-15 DOI: 10.1177/03913988241245013

Jörg Vienken, Carlo Boccato

{"title":"Do medical devices contribute to sustainability? The role of innovative polymers and device design","authors":"Jörg Vienken, Carlo Boccato","doi":"10.1177/03913988241245013","DOIUrl":"https://doi.org/10.1177/03913988241245013","url":null,"abstract":"Sustainability of a medical device has not yet become a major issue in public discussions compared to other topics with impact to material performance, clinical application, production economy and environmental pollution. Due to their unique properties, polymers (plastics) allow for multiple, flexible applications in medical device technology. Polymers are part of the majority of disposable and single use medical device and contribute with 3% to the worldwide production of plastics. The global medical polymer market size was valued 19.9 billion US-$ in 2022 and its value projection for 2023 is expected to reach 43.03 billion US-$ Here, a wider concept of related sustainability is introduced for medical devices and their polymer components. A close look on medical device specification reveals that additional properties are required to provide sustainability, such as biodegradability, quality by device design (QbD), as well as an inbuild performance service for patients, healthcare professionals and healthcare providers. The increasing global numbers for chronic and non-communicable diseases require a huge demand for single use medical devices. A careful look at polymer specification and its performance properties is needed, including possible chemical modifications and degradation processes during waste disposal. Bioengineers in charge of design and production of medical devices will only be successful when they apply a holistic and interdisciplinary approach to medical device sustainability.","PeriodicalId":519226,"journal":{"name":"The International Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140603518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-based differences in neck selectivity in total hip arthroplasty using a modular femoral neck system 使用模块化股骨颈系统进行全髋关节置换术时股骨颈选择性的性别差异

The International Journal of Artificial Organs Pub Date : 2024-04-08 DOI: 10.1177/03913988241243021

Tomonori Shigemura, Koya Kamikawa, Yohei Yamamoto, Yasuaki Murata

{"title":"Sex-based differences in neck selectivity in total hip arthroplasty using a modular femoral neck system","authors":"Tomonori Shigemura, Koya Kamikawa, Yohei Yamamoto, Yasuaki Murata","doi":"10.1177/03913988241243021","DOIUrl":"https://doi.org/10.1177/03913988241243021","url":null,"abstract":"Background:Dislocation is a major complication of total hip arthroplasty (THA). The modular femoral neck system provides practical advantages by allowing adjustment of neck version and length in the presence of intraoperative instability. Anatomical studies have identified morphological differences in the hip joint between men and women. Despite sex-based differences in hip morphology, it remains unclear whether such differences affect neck selectivity in THA using a modular neck system and whether this approach achieves anatomical reconstruction, thereby reducing complications such as dislocation. This study aimed to investigate gender differences in neck selectivity in THA with the modular neck system and assess the clinical impact of the modular neck system.Methods:A total of 163 THAs using a modular neck system were included in this study. Data on the type of modular neck and intraoperative range of motion (ROM) were retrieved from patient records. Pre- and post-operative leg length differences (LLD) were examined as part of the radiographic assessment. Dislocation was investigated as a postoperative complication.Results:Neck selectivity did not significantly differ between men and women. The comparison of pre- and post-operative LLD revealed a tendency for varus necks to improve LLD more than version-controlled necks. Furthermore, no significant correlation was found between intraoperative ROM and neck selectivity, or postoperative dislocation and neck selectivity.Conclusions:This study on THA with a modular neck system provided valuable insights into sex-based differences in neck selectivity and highlighted the potential benefits of the modular neck system in addressing LLD and preventing postoperative dislocation.","PeriodicalId":519226,"journal":{"name":"The International Journal of Artificial Organs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140603517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0