Annals of National Academy of Medical Sciences最新文献

Granulomas co-occurring in malignancies – tale of etiological relationship 并发于恶性肿瘤的肉芽肿--病因关系的故事

Annals of National Academy of Medical Sciences Pub Date : 2024-03-11 DOI: 10.25259/anams-2022-12-9-(804)

Sacheeta Babuta, C. Garg, Shashikala Vinayakamurthy, Ranjan Agrawal, A. Agarwal

{"title":"Granulomas co-occurring in malignancies – tale of etiological relationship","authors":"Sacheeta Babuta, C. Garg, Shashikala Vinayakamurthy, Ranjan Agrawal, A. Agarwal","doi":"10.25259/anams-2022-12-9-(804)","DOIUrl":"https://doi.org/10.25259/anams-2022-12-9-(804)","url":null,"abstract":"\u0000\u0000To determine the possible aetiopathogenesis of co-occurrence of granulomas with different malignancies in different body sites.\u0000\u0000\u0000\u0000All cases with granuloma formation observed in draining lymph nodes or in the primary site of malignant tumors were included in the present study. After routine histopathology examination, modified Ziehl-Neelsen (ZN) staining for Mycobacteria was carried out in all the cases. Detailed history, especially of Tuberculosis, sarcoidosis, neoadjuvant chemotherapy, radiation, or previous procedure, was recorded.\u0000\u0000\u0000\u000011 out of 35 cases (31.4%) had granulomas within the primary tumor, while 24 cases out of 35 (68.6%) showed nodal granulomas. Of the 24 cases, 5 cases had nodal metastatic tumor deposits. Also, necrotizing granulomas with AFB were significantly more as compared to AFB in non-necrotizing granulomas (p value of 0.05). Of the total cases, 20% had an attributed risk factor. Three cases received neoadjuvant chemotherapy, and three had a history of systemic tuberculosis, while one case had associated Crohn’s disease.\u0000\u0000\u0000\u0000We recommend to characterize granulomas as necrotizing/nonnecrotizing, confluent/discrete, tumor deposit present/absent; prior history of systemic/local illnesses (like SS, TB, fungal infections, IBD, etc.); prior history of CT/RT; and to follow routine ZN staining in all cases of granulomas with malignancy.\u0000","PeriodicalId":517858,"journal":{"name":"Annals of National Academy of Medical Sciences","volume":"57 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140284992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rifampicin-induced thrombocytopenia in a patient with abdominal tuberculosis 一名腹腔结核患者因利福平诱发血小板减少症

Annals of National Academy of Medical Sciences Pub Date : 2024-03-09 DOI: 10.25259/anams-2022-3-9-(585)

R. Boddu, Anish Sharma, Kundan Mishra, Suman Kumar

引用次数: 0

Comparison of seven commercial RT-PCR kits with the NIV kit for the diagnosis of Covid-19 七种商用 RT-PCR 试剂盒与 NIV 试剂盒在诊断 Covid-19 方面的比较

Annals of National Academy of Medical Sciences Pub Date : 2024-03-08 DOI: 10.25259/anams-2022-12-3-(794)

Mala Chhabra, K. Nirmal, Ankit Chauhan, A. Athotra, Stuti Kansra, Anuradha Shulania, A. Achra, N. Duggal

{"title":"Comparison of seven commercial RT-PCR kits with the NIV kit for the diagnosis of Covid-19","authors":"Mala Chhabra, K. Nirmal, Ankit Chauhan, A. Athotra, Stuti Kansra, Anuradha Shulania, A. Achra, N. Duggal","doi":"10.25259/anams-2022-12-3-(794)","DOIUrl":"https://doi.org/10.25259/anams-2022-12-3-(794)","url":null,"abstract":"\u0000\u0000Coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spread across the globe in an unprecedented manner and was declared a pandemic on March 11, 2020 by the World Health Organization (WHO). This study was carried out with the aim to compare the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and agreement of the eight different RT-PCR kits for the diagnosis of COVID-19.\u0000\u0000\u0000\u0000This observational cross-sectional study was carried out in the Department of Microbiology of a tertiary care hospital in Central Delhi from July to October 2021. A total of 45 nasopharyngeal and/or oropharyngeal swabs in Viral Transport Medium (VTM) from suspected COVID-19 patients were received in the laboratory for RT-PCR. These samples were tested by eight different Indian Council of Medical Research (ICMR)-approved RT-PCR kits with different gene targets. The comparison was made with the National Institute of Virology (NIV), the Pune COVID-19 RT-PCR kit. Statistical analysis: sensitivity, specificity, PPV, and NPV were calculated for each kit and compared using the McNemar test. Agreement of different kits was evaluated using Kappa analysis.\u0000\u0000\u0000\u0000The results of the 45 samples of suspected COVID-19 cases were recorded as per the cycle threshold (Ct) provided in the kit insert. Of these, 15 samples detected both E and RdRp genes and 30 were negative for both the genes of SARS CoV-2 by NIV, the Pune COVID-19 RT-PCR kit. All kits showed 100% sensitivity and had 100% NPV when compared with the NIV kit. However, specificity, PPV, and agreement were variable as compared to the NIV kit.\u0000\u0000\u0000\u0000The reporting should be carried out as per the manufacturer’s instructions. However, positive results with Ct values ≥ 36 showed variable results with different RT PCR kits and hence should be interpreted with caution.\u0000","PeriodicalId":517858,"journal":{"name":"Annals of National Academy of Medical Sciences","volume":"30 34","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140396819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A comparative study of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in bipolar mania and schizophrenia 双相躁狂症和精神分裂症患者的中性粒细胞/淋巴细胞比率（NLR）和血小板/淋巴细胞比率（PLR）比较研究

Annals of National Academy of Medical Sciences Pub Date : 2024-03-08 DOI: 10.25259/anams-2023-6-1-(941)

Manish Kumar Goyal, Kuldeep Singh Yadav, Ram Kumar Solanki

{"title":"A comparative study of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in bipolar mania and schizophrenia","authors":"Manish Kumar Goyal, Kuldeep Singh Yadav, Ram Kumar Solanki","doi":"10.25259/anams-2023-6-1-(941)","DOIUrl":"https://doi.org/10.25259/anams-2023-6-1-(941)","url":null,"abstract":"\u0000\u0000The role of immunological disturbance in bipolar disorder (BD) and schizophrenia has been highlighted by some studies. There are few studies available that compared the inflammatory markers between schizophrenia and BD, but only one study demonstrated the difference in terms of neutrophil/lymphocyte ratio (NLR) and Platelet/lymphocyte ratio (PLR) between them. So this study was conducted to compare the NLR and PLR values among schizophrenia, bipolar mania, and healthy controls in order to find out a potential biomarker for these disorders.\u0000\u0000\u0000\u0000Eighty consecutive patients suffering from bipolar mania, 80 suffering from schizophrenia, and 80 healthy controls were recruited in the psychiatric center situated at a tertiary care hospital. Blood samples of all groups were transferred to the laboratory for complete blood count analysis. Thereafter, all the groups were compared by applying proper statistics.\u0000\u0000\u0000\u0000Significant higher level of neutrophil count and NLR value was seen in both bipolar mania and schizophrenia groups compared to healthy controls. There was no difference observed between schizophrenia and the bipolar mania group regarding NLR, PLR, neutrophils, lymphocytes, and platelets values.\u0000\u0000\u0000\u0000NLR has appeared as a potential marker in our study, and it reflects a state of low-grade inflammation in both schizophrenia and bipolar mania. BD and schizophrenia have been considered as part of one continuum, which is also supported by the findings of our study. These markers can help in the prognosis and treatment of at least a subsection of patients and also are inexpensive and easy to assess.\u0000","PeriodicalId":517858,"journal":{"name":"Annals of National Academy of Medical Sciences","volume":"32 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140396787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0