Mutiara Medika: Jurnal Kedokteran dan Kesehatan最新文献

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Risk Factors of Breast Cancer in Patients at Dr. Doris Sylvanus Hospital, Palangka Raya 巴朗卡拉雅Doris Sylvanus医生医院患者患乳腺癌的风险因素

Mutiara Medika: Jurnal Kedokteran dan Kesehatan Pub Date : 2024-03-08 DOI: 10.18196/mmjkk.v24i1.19067

Dian Ana Mutriqah, Nia Kania, R. Panghiyangani, Husaini Husaini

{"title":"Risk Factors of Breast Cancer in Patients at Dr. Doris Sylvanus Hospital, Palangka Raya","authors":"Dian Ana Mutriqah, Nia Kania, R. Panghiyangani, Husaini Husaini","doi":"10.18196/mmjkk.v24i1.19067","DOIUrl":"https://doi.org/10.18196/mmjkk.v24i1.19067","url":null,"abstract":"Breast cancer ranks first in contributes to cancer deaths in Indonesia. This study aims to analyze the relationship between menarche age, level of knowledge, and history of the use of control birth pills and the incidence of breast cancer. This study employed a case-control design. Inclusion criteria for the case group were women, 20–50 years, breast cancer patients, junior high education level, and married. The subjects excluded respondents who used contraception. The data comes from questioner and medical record. There were 27 respondents each for the case and control group. The result showed a major age range of 31–40 years (63.0%). The education level was dominated by junior high school (40.7%). The chi-square test showed a correlation between the age of menarche (p = 0.01) OR 5.50 (95% CI: 1.604 -18.864), and knowledge (p = 0.00) OR value of 8.31 (95% CI: 2.437-28.354) with breast cancer, but no correlation between history of use of pills contraception with breast cancer (p = 0.74). The dominant risk factor for breast cancer in patients at Dr. Doris Sylvanus Hospital was the level of knowledge. Increasing knowledge about cancer is important in preventing breast cancer in women, especially in Palangkaraya.","PeriodicalId":517636,"journal":{"name":"Mutiara Medika: Jurnal Kedokteran dan Kesehatan","volume":"33 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140285623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro Cytotoxicity Evaluation of Dandelion Root Ethanol Extract on PANC-1 Cell Line 蒲公英根乙醇提取物对 PANC-1 细胞株的体外细胞毒性评估

Mutiara Medika: Jurnal Kedokteran dan Kesehatan Pub Date : 2024-03-05 DOI: 10.18196/mmjkk.v24i1.20917

Aliye İrem Aras, Emine Arslan, Büşra Özçay

{"title":"In vitro Cytotoxicity Evaluation of Dandelion Root Ethanol Extract on PANC-1 Cell Line","authors":"Aliye İrem Aras, Emine Arslan, Büşra Özçay","doi":"10.18196/mmjkk.v24i1.20917","DOIUrl":"https://doi.org/10.18196/mmjkk.v24i1.20917","url":null,"abstract":"A challenging diagnosis is the outcome of pancreatic cancer's aggressivity and malignant character. This type of cancer is mostly detected in the metastatic stage. Current treatment options have various side effects, result in the survival rates and quality of life of patients are extremely decreased. Dandelion (Taraxacum officinale (L.) Weber ex F.H. Wigg.) is one of the natural products that has the potential to be therapeutic against a wide range of diseases. This study aimed to evaluate the potential of ethanol extract of dandelion root (DRE) as an alternative anticancer agent. Based on this purpose, milk-rich dandelion roots were collected, cut into small pieces, and then extracted using Soxhlet in the presence of 70% ethanol. The cytotoxic effect of the DRE at certain doses (10, 5, and 2.5 mg/mL) was determined by the Microtetrazolium (MTT) assay for 24, 48, and 72 hours, and half-maximal inhibitory concentration (IC)50 values for these incubation periods were found to be 10 mg/mL, 6.80 mg/mL and 6 mg/mL (p0.001), respectively. As a result, DRE may reduce cell viability when applied to aggressive pancreatic cancer cells and may have the potential to be an alternative anticancer agent. This potential can be clarified with further studies.","PeriodicalId":517636,"journal":{"name":"Mutiara Medika: Jurnal Kedokteran dan Kesehatan","volume":"25 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140286020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0